Protein Alignment nAChRalpha6 and lgc-29

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001317792.1
• Gene: lgc-29 / 3896858
• WormBaseID: WBGene00044528
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 330
• Identity: 81/330 - (24%)
• Similarity: 152/330 - (46%)
• Gaps: 45/330 - (13%)

  Fly    29 HEKRLLNHLLSTYN-------TLER-PVANES-EP--LEVKFGLTLQQIIDVDEKNQILTTNAWL 82
            |:.||...|..:|:       ||.. |..|.: .|  .|:...|::.::::|.|..:..|.....
 Worm    37 HQDRLFEKLFKSYDPGINAIYTLHSVPETNGTVHPPRFEITIQLSMMKLVEVVEPEEKATFLFDY 101

  Fly    83 NLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLM---YNSADEGFDGTYHTNIVVKHNGSC-L 143
            ..:|.|..|.|:..:|||:..:.:..:|:|.|:..:   ::|..:.||..|.....:..|||. :
 Worm   102 RADWYDTRLSWDPEDYGGINHIYVPRSKVWIPETTIVDCFSSEIKVFDNEYTRYAWLHSNGSIGM 166

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLS---DFITNGEWYL 205
            |: ..:....|::|:..||.|...|.:.|...||...:..:|..:   |.|.   :.:.||||.:
 Worm   167 YI-ASVTSVVCQMDVYKFPMDTHTCSVNFLFMTYQLEEFTIVGKT---GTLPRPVEQLGNGEWQM 227

  Fly   206 LAMPGKKNTIVYACCPEPYVD-----ITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
                 |...|.:    ||.||     ..|.....|...:|...:::|...|:.::::...:..::
 Worm   228 -----KSIQIAF----EPVVDNLTYLTKFEATFSRNPGFYIVLVMIPAYFINVLSIVALFMDINN 283

  Fly   266 -GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFL-NLVAETLPQVSDAIPL 328
             .||.|:|:|.::|::..|.::||.:|.|.: :|::.:..:.||.:.| :|.|..      |:|.
 Worm   284 RSEKFTVGMTNIMSMSFILVILAEDLPKTKN-LPILAIYTVTSLAIMLCSLTAVV------ALPK 341

  Fly   329 LGTYF 333
            |..|:
 Worm   342 LKAYY 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	81/330 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	46/192 (24%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)
lgc-29	NP_001317792.1	LIC	38..>337	CDD:455710	76/312 (24%)