Protein Alignment nAChRalpha6 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 198/559 - (35%)
• Similarity: 296/559 - (52%)
• Gaps: 113/559 - (20%)

  Fly    10 SLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQ 74
            |:.||:.| :::..|   ..|:||:..|...||.|.|||.|.::.:.|:|||...|:|:|:||||
  Fly    12 SILVLVAF-SLVSAS---EDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72

  Fly    75 ILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHN 139
            |:.:|.||.|.|.||.|:|:|.:|||:..||:.|:|:||||::::|:||..::..|.:|:::...
  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137

  Fly   140 GSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL-NSEDGGDLSDFITNGEW 203
            |..|:|||.|::|:|.||:|:||||.|.|.|||||||::|:|:.|.| |:::..||||:..:|.|
  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202

  Fly   204 YLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEK 268
            .::.:|...|............||||.|.|||:||:|..|||:|.||||.:.:|.|.||.::|||
  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267

  Fly   269 LTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYF 333
            :|||::|||||.|||.||::.:|.||..:|||...:|  .|..:|.|
  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLL--FTFIMNTV------------------ 312

  Fly   334 NCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNR 398
                     |:::||:::|::.|....|.||.:|:|:||.:||..|.|.||     |||.|  ..
  Fly   313 ---------SILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRP-----RKTRL--RW 361

  Fly   399 MKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNH------ 457
            |.|:                         .|.........|:|.|..:.:|.:|||...
  Fly   362 MMEM-------------------------PGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVM 401

  Fly   458 --KDLH-------------------------------LIL--------KELQFITARMRKADDEA 481
              .|||                               ::|        :.::||...:|..|...
  Fly   402 ELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYI 466

  Fly   482 ELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            :...|||:.|||:||..|.:|.:.|...||.:|:.||||
  Fly   467 QTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHI 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	193/553 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	82/181 (45%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	193/552 (35%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	94/208 (45%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)