DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and acr-25

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001023570.2	Gene:	acr-25 / 3565563	WormBaseID:	WBGene00043066	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	211/571 - (36%)
Similarity:	301/571 - (52%)	Gaps:	104/571 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            |.:.||:.:.......|..|...||..|..||||:.|.||.:.||.||.||||:|||||||::..
Worm    10 LCLLLALGRNGITQKSEGDLYTELLEDYEPLERPIENSSEAVMVKMGLVLQQIVDVDEKNQVVDV 74

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            ||||...|.||:|:|...:||||.|||....:||.||||||||||..||..|.:|::|..||...
Worm    75 NAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNLLVYPNGLVN 139

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAM 208
            ::|||:::.:|||.:.|||||.|.|.:||||||:||.:|:|.:: ::|.|:|:::.||||.|...
Worm   140 WMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLEID-DNGFDISNYMQNGEWTLEGT 203

  Fly   209 PGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGV 273
            ..|:|...|.||||||.|:.||..||||.|||.||||:||:||:.:.|:|||.|||:|||::|.:
Worm   204 TVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTLVGFTFPPDAGEKMSLQI 268

  Fly   274 TILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMF 338
            ||:||:.:|.|.|||..|.||:||                             |.|..:|...:|
Worm   269 TIMLSICIFQNYVAELSPPTSEAV-----------------------------PFLSAFFAVCLF 304

  Fly   339 MVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELE 403
            ..|..|..|.:.||:||||...|:|....:.:.|:|:||:|.|.||| .:.|...::.....|.|
Worm   305 TCACCVTATTLALNFHHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPG-YVARCGKIVKQDDSEDE 368

  Fly   404 LKERSSK---SLLANVL-----------------------------------------DIDDD-- 422
            .:||.::   ..:|.::                                         :.|||
Worm   369 FEERQTRLDQQRIATIISQITVESNKPTPTFPRRVTIVDEVNSDGEAEEPLPPDEVIREEDDDVA 433

  Fly   423 -------FRHTISGSQTA-------IGSSASFGRPTTVEEHHTAIGCNHKDLHLILKE----LQF 469
                   :|.|.:.||..       ..::...|....||:....         |:|::    |..
Worm   434 SMDDPPAWRSTTTTSQPPQSPAHLWWNATNRMGNRVPVEQIAQL---------LVLQQVHGHLSE 489

  Fly   470 ITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            |...:|:.:...::..||||:|:||||.|:::||.|...:||.:..|.|:|
Worm   490 INKHIREREKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFASVPNI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	208/566 (37%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	95/180 (53%)
acr-25	NP_001023570.2	Neur_chan_LBD	26..231	CDD:280998	107/205 (52%)
acr-25	NP_001023570.2	Neur_chan_memb	239..534	CDD:280999	91/333 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.840