Protein Alignment nAChRalpha6 and lgc-28

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001022053.1
• Gene: lgc-28 / 3565225
• WormBaseID: WBGene00044301
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 389
• Identity: 84/389 - (21%)
• Similarity: 147/389 - (37%)
• Gaps: 98/389 - (25%)

  Fly     7 ASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVA---NESEPLEVKFG-------L 61
            |.||:|.|.|.|    |...|..|||     ......|...:.   :::.|:: |.|       |
 Worm     8 ALLSMFSLNIQL----EPSPGEMEKR-----YEAETKLREDITKRFDDTMPIK-KDGYLQLIPLL 62

  Fly    62 TLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWK-----PDVLMYNS 121
            .:..|.|:.::..:|.........|.|..|.||.:.|.|::....|.:::|:     |.::|.:.
 Worm    63 HVDHIHDIQDEQGVLKMALTFTFTWMDERLMWNPSNYSGIRTFSTTRHEMWRKKFWTPTLMMTDV 127

  Fly   122 AD--------EGFDGTYHTNIVVKHNG-------SCLYVPPGIFKSTCKIDITWFPFDDQHC--- 168
            .:        :.||    .:|.:..:|       ..|.:|       |:.....:|.|.::|
 Worm   128 PNSRRPSDVFKPFD----MDIYISSSGMVRTSARMMLTIP-------CRTGFGSYPNDYKNCTFT 181

  Fly   169 --------EMKFGSWTYDGNQLDLVLNSEDGGDLSDF----ITNGEWYLLAMPGKKNTIVYA--- 218
                    :.:|..|  .|.:....|.|....|:.||    |....:|:..  |.:....::
 Worm   182 LMSPYYADQFRFAQW--GGAEFTRYLMSSRVTDVLDFQLINIDTRNYYMFL--GSEVVDDFSKFK 242

  Fly   219 --CCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLIS-SMALLGFTLPPDSGEKLTLGVTILLSLT 280
              .|...|   .:.:.::|...:....||.|..:|: .:|:.|| ||...|  |....:.|:..|
 Worm   243 PRHCRSFY---RYNLVLKRVNKFVSVQLIAPISVIAVFLAISGF-LPHFYG--LVCAGSALVYET 301

  Fly   281 VFLNLVAESMPTTSDAVPLIGV---------TILLSLTVF-LNLVAETLPQVSDAIPLLGTYFN 334
            :|...|.:.:|.....:|:|.:         .:||:..|| :|..:.|   |..|.|   .||:
 Worm   302 IFTYDVEQVLPKDYSGMPMIAILLCFLFAETIVLLAWKVFSINTRSHT---VFTAFP---EYFD 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	81/385 (21%)
		LGIC_ECD_nAChR	55..236	CDD:349798	40/227 (18%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	25/135 (19%)
		LIC	67..>329	CDD:273305	56/282 (20%)
		Cys-loop	164..178	CDD:349787	3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010