Protein Alignment nAChRalpha6 and deg-3

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001379138.1
• Gene: deg-3 / 3565200
• WormBaseID: WBGene00000951
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 537
• Identity: 154/537 - (28%)
• Similarity: 249/537 - (46%)
• Gaps: 97/537 - (18%)

  Fly    32 RLLNHLLS--TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWN 94
            ||..||||  .|:...||:.:..:.|:|...::|.|||:|||.:|.:..|.|:..:|.|..|.||
 Worm    53 RLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNIKLNVWMIQKWRDEYLDWN 117

  Fly    95 ETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGT-YHTNIVVKHN------GSCL-YVPPGIFK 151
            ..|||.:....|..:.||.||..:|||.....|.| .:.||....|      |:.| ::.|.|:.
 Worm   118 PNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNYWKGEKGAELSFLYPAIYT 182

  Fly   152 STCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIV 216
            .||:::|.:||:|.|:|.:...|||...:.||...::|  ..:..||.|.||.:.:....::...
 Worm   183 ITCRLNIRFFPYDRQNCTLTISSWTNSKSALDYYADTE--VSMQSFIPNEEWQVKSFKIHRHEYK 245

  Fly   217 YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP----PDSGEKLTLGVTILL 277
            ||||.||:|.:..::.|:|:.|||..|||:|..:|:.:|:.||..|    .|..||:.||:|.||
 Worm   246 YACCAEPWVILQASLVIQRKPLYYLVNLIIPTSIITLVAITGFFTPASTDDDRTEKINLGITTLL 310

  Fly   278 SLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVAS 342
            ::::.:.:|::.|||||:.|||| ....||:.:.::               :||:
 Worm   311 AMSILMLMVSDQMPTTSEFVPLI-AWFYLSIIIIIS---------------IGTF---------- 349

  Fly   343 SVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP----------------------- 384
               ||.|||:...|.......|.:|:.:|...||.:|.:..|
 Worm   350 ---LTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLLNVPPPLQTLWGELDDDPLNVRRRKKS 411

  Fly   385 ---GRKITRKTILLSNRMKELELKER----SSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGR 442
               .|.:...:..:::.|..|.:.:.    |.|.....::|:      |...|.....|.|....
 Worm   412 HYLSRNVNNGSTKMASPMSTLRVPQSAGSVSEKRQSFQMIDV------TSPNSPNTARSRAPSLA 470

  Fly   443 PTTV-----EEHHTAIGCNHKDL----HLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC 498
            |:|.     |...:|:...:..|    ::..||:.    .||:   :.:...:|:|.|.|:|||.
 Worm   471 PSTAKATMWEGTMSALAGTNTQLRRTSNVFNKEVD----EMRR---KRQCSLEWEFLATVLDRFL 528

  Fly   499 LIVFTLFTIIATVTVLL 515
            ||||....:|.|..::|
 Worm   529 LIVFVGAVVIVTAGLIL 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	154/537 (29%)
		LGIC_ECD_nAChR	55..236	CDD:349798	64/188 (34%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
deg-3	NP_001379138.1	Neur_chan_LBD	53..266	CDD:460752	74/214 (35%)
		LGIC_TM_cation	267..>357	CDD:349853	39/118 (33%)
		TM1 helix	267..291	CDD:349853	11/23 (48%)
		Neur_chan_memb	273..543	CDD:460753	75/311 (24%)
		TM2 helix	303..324	CDD:349853	6/20 (30%)
		TM3 helix	335..357	CDD:349853	9/49 (18%)