Protein Alignment nAChRalpha6 and HTR3A

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_998786.3
• Gene: HTR3A / 3359
• HGNCID: 5297
• Length: 510
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 132/518 - (25%)
• Similarity: 234/518 - (45%)
• Gaps: 85/518 - (16%)

  Fly    32 RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNET 96
            ||.::||:.|....|||.:..:|..|...:.:..|::||||||:|||..|....|.|..|:||..
Human    36 RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 100

  Fly    97 EYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWF 161
            ::..:..|.|..:.:|.||:|:....|.|..... ..:.::|.|......|....:.|.:||..|
Human   101 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNF 164

  Fly   162 PFDDQHCEMKFGSWTYDGNQLDLV---LNSEDGGDLSDFITNGEWYLL-AMPGKKNTIVYACCPE 222
            |||.|:|.:.|.||.:....:::.   |..:...|.|.|:..|||.|| .:|..:...:.:  ..
Human   165 PFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES--SN 227

  Fly   223 PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVA 287
            .|.::.|.:.||||.|:|..:|::|.:.:..|.::||.|||:|||:::..:|:||..:|||.:|:
Human   228 YYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVS 292

  Fly   288 ESMPTTSDAVPLIG---------------VTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIM 337
            :::|.|:...||||               .:.||.::            ::.|:...|.||...|
Human   293 DTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVS------------LASALGCTGVYFVVCM 345

  Fly   338 FMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKEL 402
            .::..|:..|:.::...|:......:|.|::.:.|:.:.|:|                  .::|.
Human   346 ALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLL------------------CLREQ 392

  Fly   403 ELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSAS-FGRPTTVE--------------EHHTA 452
            ...:|...:..|...|           ..:|:|:..| .|.|...|              |...|
Human   393 STSQRPPATSQATKTD-----------DCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA 446

  Fly   453 IGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            : |.      :|:||..|...:.|.|:..|:..||.....|:|:....::.|..:..::|:::
Human   447 V-CG------LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	132/518 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	54/184 (29%)
HTR3A	NP_998786.3	LIC	23..504	CDD:273305	132/518 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910