DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and nAChRalpha3

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster

Alignment Length:	785	Identity:	218/785 - (27%)
Similarity:	316/785 - (40%)	Gaps:	309/785 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            :::.|:.|..|...|..|||.:.|||.||.|.|||.|.::.|.|:..|.|.|:|||:.||||:||
  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            |.|:...|.||.|:|...|||||:.|.:..:.:|:||:::||:||..|:.|..|...:.:.|...
  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL----VLNS----EDGGDLSDFITN 200
            :.||.|:||:|:||:.:||||:|.|.||||||||||.|:||    .||.    |.|.|||:|.|:
  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTS 204

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            .||.:|.:|..:|...|.||.|||:||||.|.:||:||:|..|||:||:.||.:.:|.|.||.||
  Fly   205 VEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS 269

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||::|.::||||||||..|:||.:|.||..|||:|..:|.::                   :|.
  Fly   270 GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTM-------------------ILD 315

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP----------G 385
            |:          |:.:||:|||.|.|:...|.|.||:::||:..||..|.|.||          .
  Fly   316 TF----------SICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSS 370

  Fly   386 RKITRKT----------------ILLSNRMKELELKERSSKSLLA------NVLD---------- 418
            |::..:|                :.||......:...||:...|.      |::|
  Fly   371 RRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGA 435

  Fly   419 ----------------------------IDDDFRH----------------------TISGSQTA 433
                                        ||..:.:                      |.:.|||.
  Fly   436 STITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTG 500

  Fly   434 -IGS---------------------------SASFG---------------------------RP 443
             .||                           ||:|.                           ..
  Fly   501 QNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKST 565

  Fly   444 TTV-------------------------------------------------------EEHH--- 450
            |||                                                       ::||
  Fly   566 TTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQ 630

  Fly   451 ------------------------------TAIG--------------------------CNHK- 458
                                          .|.|                          |:.:
  Fly   631 RPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRG 695

  Fly   459 ----------DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513
                      :||..:..:.:|..:.||.::...:..|||:.|||:||..|.:||:..::.|..:
  Fly   696 NVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGI 760

  Fly   514 LLSAP 518
            :|.||
  Fly   761 ILQAP 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	216/782 (28%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	91/188 (48%)
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	105/214 (49%)
		Neur_chan_memb	248..>359	CDD:280999	55/139 (40%)
		Neur_chan_memb	<683..760	CDD:280999	18/76 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940