Protein Alignment nAChRalpha6 and chrnb3b

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_775394.1
• Gene: chrnb3b / 317643
• ZFINID: ZDB-GENE-030102-4
• Length: 462
• Species: Danio rerio
• Alignment Length: 489
• Identity: 171/489 - (34%)
• Similarity: 257/489 - (52%)
• Gaps: 71/489 - (14%)

  Fly    30 EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWN 94
            |..||..|...|....||:.:.:..::|:|||.:.|::|||||||::|||.||..||.||.||||
Zfish    31 EDALLRDLFQGYQRWVRPILHANHTVKVRFGLKISQLVDVDEKNQLMTTNVWLYEEWLDYKLRWN 95

  Fly    95 ETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            ...|||:..:|:....:|.||:::|.:||..|:|:..|..:|::||...:.||..:||.|.:|:|
Zfish    96 PENYGGITFIRVPSESIWLPDIVLYENADGRFEGSIMTKAIVRYNGLITWTPPASYKSACTMDVT 160

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPY 224
            :||||.|:|.|||||||||||.::|||.:.. .|.|||..||||.:|:..|.|.:........||
Zfish   161 FFPFDRQNCSMKFGSWTYDGNMVELVLVNHQ-VDRSDFFDNGEWEILSATGHKGSRRDGHYSYPY 224

  Fly   225 VDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAES 289
              ||::..::|..|:|...||:||:.:|.:.:|.|.||.|.|||::|..::|:||||||.::.|.
Zfish   225 --ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKVSLSTSVLVSLTVFLLVIEEI 287

  Fly   290 MPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYH 354
            :|::|..:||||..:|.                             ||..|..|:::||.|:|.|
Zfish   288 IPSSSKVIPLIGEYLLF-----------------------------IMIFVTLSIIVTVFVINVH 323

  Fly   355 HR-TADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLD 418
            || :|..|.|.||::::|||.||.:|.|    |..|.:........:..:||.||.|
Zfish   324 HRSSATYHPMSPWVRTLFLQRLPDLLCM----RGNTDRYHYPQMEPQSPDLKPRSKK-------- 376

  Fly   419 IDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAEL 483
                                  |.|....:....|..    |......:::|:..::|.....|:
Zfish   377 ----------------------GPPGPEGDGQALINM----LEQATNSVRYISRHIKKEHFIREV 415

  Fly   484 IGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            :.||||.|.|:||..|..|...:::.|:.:...|
Zfish   416 VQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	170/487 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrnb3b	NP_775394.1	LIC	5..449	CDD:455710	170/487 (35%)