DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and Chrne

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_017452660.1	Gene:	Chrne / 29422	RGDID:	2353	Length:	547	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	150/512 - (29%)
Similarity:	251/512 - (49%)	Gaps:	77/512 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QGPHEK-RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDY 89
            ||.:|: .|.:||...|:...|||....:.:.:...:||..:|.::||.:.|||:.|:.:||.||
  Rat    72 QGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDY 136

  Fly    90 NLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTC 154
            .|.:::.::.||:.||:....:|.|::::.|:.|..|...|..|::|...||..::||.|::|||
  Rat   137 RLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTC 201

  Fly   155 KIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITNGEWYLLAMPGK 211
            .:::|:||||.|:|.:.|.|.||:..:::.:...:|.|        |.:.|..||||.:...||.
  Rat   202 AVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGM 266

  Fly   212 KNTIVYACCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS-GEKLTLGVT 274
            ..........:| ..|:.:|:.|||:.|:|..|:||||||||.:.||.:.||..: |:|.|:.:.
  Rat   267 IRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSIN 331

  Fly   275 ILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFM 339
            :||:.||||.|:|:.:|.||.:|||:|     ...:|:.:||..:            ..||
  Rat   332 VLLAQTVFLFLIAQKIPETSLSVPLLG-----RYLIFVMVVATLI------------VMNC---- 375

  Fly   340 VASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRM---------GRPGRKITRKTILL 395
                    |:|||...||...|...|.::.:.|:.||.:|.:         ..|.|:.:...|||
  Rat   376 --------VIVLNVSLRTPTTHATSPRLRQILLELLPRLLGLSPPPEDPGAASPARRASSVGILL 432

  Fly   396 SNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQT--AIGSSASFGRPTTVEEHHTAIGCNHK 458
              |.:||.||:..|:.:.       :..||. .|:.|  |:..:.|...|
  Rat   433 --RAEELILKKPRSELVF-------EGQRHR-HGTWTAAALCQNLSAAAP--------------- 472

  Fly   459 DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCL-IVFTLFTIIATVTVL 514
            ::...:..:.|:....|..:...|.:.||......:|..|. ....||::.:|:..|
  Rat   473 EVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	150/512 (29%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	60/189 (32%)
Chrne	XP_017452660.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000