Protein Alignment nAChRalpha6 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_434693.1
• Gene: Chrnb4 / 25103
• RGDID: 2351
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 188/525 - (35%)
• Similarity: 287/525 - (54%)
• Gaps: 68/525 - (12%)

  Fly    11 LFVLLIFLAIIKESCQ-GPHEKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            |.::.:|..:....|: ...|::|::.||  :.||.|.||..:.|:.:.::..|:|.|:|.|:|:
  Rat     6 LLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNER 70

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            .||:||:.||..||.||.|.||.:.|.||..|||...::|.||:::||:||..::.:.:||::|:
  Rat    71 EQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVR 135

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202
            .|||..::||.|:||.|||::..||||.|:|.:||.|||||..::|:||.|.. ..:.||..:||
  Rat   136 SNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPT-AIMDDFTPSGE 199

  Fly   203 WYLLAMPGKKNTIVYACCPE--PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            |.::|:||::..     .|:  .|||:|:...|:|:.|:|..|||:|||||:|:|:|.|.||.|.
  Rat   200 WDIVALPGRRTV-----NPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDC 259

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||:||.:::||:||.||.|:::.:|.||..:||||..:|.:
  Rat   260 GEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFT----------------------- 301

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILL 395
                  |.:|..|:|.||.|||.|||:...|.|..|:|..||..||..|.|.|||.:::...:..
  Rat   302 ------MVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPH 360

  Fly   396 SNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASF-----GRPTTVEEHHTA--- 452
            .::: .|...:.::.|.|..            :......|||..|     ..|.:....|||
  Rat   361 PSQL-HLATADTAATSALGP------------TSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLP 412

  Fly   453 -------IGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIAT 510
                   .|...:||...|:.:.||...:...|.:..:|.||||.||||||..|.||....|:.|
  Rat   413 RDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGT 477

  Fly   511 VTVLL 515
            :.:.|
  Rat   478 MGLFL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	188/525 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	77/182 (42%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
Chrnb4	NP_434693.1	LIC	21..483	CDD:455710	185/510 (36%)
		LGIC_ECD	53..230	CDD:475126	77/182 (42%)