Protein Alignment nAChRalpha6 and Chrna3

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_434692.2
• Gene: Chrna3 / 25101
• RGDID: 2345
• Length: 499
• Species: Rattus norvegicus
• Alignment Length: 517
• Identity: 195/517 - (37%)
• Similarity: 291/517 - (56%)
• Gaps: 38/517 - (7%)

  Fly     5 LPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDV 69
            ||..||:.:|::.|.....:.:..|  ||..:|...||.:.|||||.|.|:.::|.:::.|::.|
  Rat     6 LPPPLSMLMLVLMLLPAASASEAEH--RLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKV 68

  Fly    70 DEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNI 134
            ||.|||:.||.||...||||.|:|..::|.||:.:|:...|:||||:::||:||..|.....|..
  Rat    69 DEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKA 133

  Fly   135 VVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFIT 199
            ::|:.|...::||.||||:||||:|:||||.|:|.||||||:||..::||||.. ...:|.|:..
  Rat   134 LLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWE 197

  Fly   200 NGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD 264
            :|||.::..||.|:.|.|.||.|.|.|||:::.|||..|:|..|||:||:|||.:.:|.|.||.|
  Rat   198 SGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSD 262

  Fly   265 SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLL 329
            .|||:||.:::||||||||.::.|::|:||..:||||..:|.:
  Rat   263 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFT---------------------- 305

  Fly   330 GTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP--GRKITRKT 392
                   |..|..|:|:||.|||.|:||...|.||.|:|:|||..||.::.|.||  |...|.||
  Rat   306 -------MIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKT 363

  Fly   393 -ILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIGC 455
             ......:..|....|:............|.........:..|.: ||:..|.::.|.....:..
  Rat   364 RTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSL 428

  Fly   456 N--HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            :  ..::...::.:::|...|:..:...|:..|||:.|||:||..|.||.|..|:.|..:.|
  Rat   429 SALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	191/511 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
		Cys-loop	154..168	CDD:349798	10/13 (77%)
Chrna3	NP_434692.2	LIC	24..490	CDD:455710	188/497 (38%)
		LGIC_ECD_nAChR_A3	29..235	CDD:349817	97/208 (47%)
		Cys-loop	153..167	CDD:349817	10/13 (77%)