Protein Alignment nAChRalpha6 and Chrna9

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001074573.1
• Gene: Chrna9 / 231252
• MGIID: 1202403
• Length: 479
• Species: Mus musculus
• Alignment Length: 538
• Identity: 191/538 - (35%)
• Similarity: 285/538 - (52%)
• Gaps: 83/538 - (15%)

  Fly     1 MDSPLPASLSLFVLLIFLAI-IK--ESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLT 62
            |:.|.|. :| |..:.|.|. ||  |:..|.:.::|.:.|...|:...|||.:....|.|...:|
Mouse     1 MNRPHPC-IS-FCWMYFAASGIKAVETANGKYAQKLFSDLFEDYSNALRPVEDTDAVLNVTLQVT 63

  Fly    63 LQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFD 127
            |.||.|:||:|||||...|:...|:|..|.|:..:|.|:..:||..:.:|:||:::||.||:...
Mouse    64 LSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESS 128

  Fly   128 GTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG 192
            ...:||:|::::|...:..|.|.||:|.:|:|:||||.|.|.:.||||||:|||:| :.|:.|.|
Mouse   129 EPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVD-IFNALDSG 192

  Fly   193 DLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALL 257
            ||||||.:.||.:..||..||.|.|.||.|||.|:|||:.::||:.:|..||::||||||.:|.|
Mouse   193 DLSDFIEDVEWEVQGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPL 257

  Fly   258 GFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQV 322
            .|.||..||||::|||||||::|||..:|||.||                              .
Mouse   258 SFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMP------------------------------A 292

  Fly   323 SDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL-------- 379
            |:.:||:|.|:...|.::.:|..||::|:|.|...|:...:|.|.|.|.|:::..||
Mouse   293 SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGES 357

  Fly   380 ----RMGRPGRKITR------KTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAI 434
                |..:...:||:      .:.|.::|.|:|..|:...| ||.|.|           |.|..|
Mouse   358 CLSPRHSQEPEQITKVYGKLPGSNLKASRNKDLSRKKELRK-LLKNDL-----------GYQGGI 410

  Fly   435 GSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCL 499
                    |...:.:........|::..|.|.|:...|...|.       .:||..|.|:|||.:
Mouse   411 --------PQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKG-------SEWKKVAKVIDRFFM 460

  Fly   500 IVFTLFTIIATVTVLLSA 517
            .:|  |.::..:|||:.|
Mouse   461 WIF--FAMVFVMTVLIIA 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	186/526 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
Chrna9	NP_001074573.1	LIC	10..474	CDD:455710	185/523 (35%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	90/206 (44%)
		Cys-loop	155..169	CDD:349823	8/13 (62%)