Protein Alignment nAChRalpha6 and GABRR3

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 70/293 - (23%)
• Similarity: 124/293 - (42%)
• Gaps: 59/293 - (20%)

  Fly    54 PLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVK-DLRITPNKLWKPDVL 117
            |:.|...:.::.|..:.|.|...|...:|...|.|..|.:..|....:. |.|:| .|:|.||:.
Human    82 PVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLT-RKIWVPDIF 145

  Fly   118 MYNSADEGFDGTYHTNIVVK-H-NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGN 180
            ..:|.......|...||::: | :|:.|........:.|.:|.:.||.|.|:|.::..|:.|:.:
Human   146 FVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNED 210

  Fly   181 QLDLV-------LNSEDGGDLSDFI-------------TNGEWYLLAMPGKKNTIVYACCPEPYV 225
            .|.|.       ||:|:...||.|.             ::..||        |.:.
Human   211 DLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWY--------NRLF--------- 258

  Fly   226 DITFTIQIRRRTLYYFFNLIVPCVLISSMALLGF-----TLPPDSGEKLTLGVTILLSLTVFLNL 285
             |.|.  :||...::......|.:|:..::.:.|     .:|    .:::||:|.:|:::..:..
Human   259 -INFV--LRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVP----ARVSLGITTVLTMSTIITA 316

  Fly   286 VAESMPTTSDAVPLIGVTILL---SLTVFLNLV 315
            |:.|||..|   .|..|.:.|   ||.|||:::
Human   317 VSASMPQVS---YLKAVDVYLWVSSLFVFLSVI 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	70/293 (24%)
		LGIC_ECD_nAChR	55..236	CDD:349798	47/203 (23%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:455710	70/293 (24%)
		LGIC_ECD_GABAAR_rho	82..267	CDD:349806	49/205 (24%)
		Cys-loop	184..198	CDD:349806	6/13 (46%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573	347..448		70/293 (24%)