DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and HTR3D

DIOPT Version :10

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:XP_054201603.1 Gene:HTR3D / 200909 HGNCID:24004 Length:456 Species:Homo sapiens


Alignment Length:367 Identity:89/367 - (24%)
Similarity:135/367 - (36%) Gaps:70/367 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKL 111
            ||.|.|....|....||..|.:.  .::|.|.|......|::..::||..|.||:|...:....|
Human    55 PVTNYSVATHVNISFTLSAIWNC--YSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENL 117

  Fly   112 WKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWT 176
            |..||.:..|.|:...|...:..:||...:.:        |.|                   .|:
Human   118 WLSDVFIEESVDQTPAGLMASMSIVKATSNTI--------SQC-------------------GWS 155

  Fly   177 YDGNQLDLVLNSEDGGD---------------LSDFITNGEWYLLAMPGKKNTIVYACCPEPYVD 226
            ...|....:..|.|..:               .:.|.|..||.||.:  :|.||........|..
Human   156 ASANWTPSISPSMDRAEPRAWRRMSRSFQIHHRTSFRTRREWVLLGI--QKRTIKVTVATNQYEQ 218

  Fly   227 ITFTIQIRR--RTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAES 289
            ..|.:.||.  |...|..|.:||..::.::..|.|.||.:||......:|:||..:|||.::.:.
Human   219 AIFHVAIRHRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDL 283

  Fly   290 MPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFN-CIMFMVASSVVLTVVVLNY 353
            :|.||       .:...||...|.|:...||        .|.||. |:..||.|.:....:....
Human   284 LPATS-------TSSHASLVAPLALMQTPLP--------AGVYFALCLSLMVGSLLETIFITHLL 333

  Fly   354 HHRTADIHEMPPWIKSVFL------QWLPWILRMGRPGRKIT 389
            |..|.....:|.|:.|:.|      :..|...:.|..|..:|
Human   334 HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLT 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:455710 89/367 (24%)
LGIC_ECD_nAChR 55..236 CDD:349798 42/197 (21%)
Cys-loop 154..168 CDD:349798 1/13 (8%)
HTR3DXP_054201603.1 LGIC_ECD 30..228 CDD:475126 46/203 (23%)
LGIC_TM_5-HT3 232..455 CDD:349865 42/159 (26%)
TM1 helix 232..256 CDD:349865 6/23 (26%)
TM2 helix 264..285 CDD:349865 6/20 (30%)
TM3 helix 310..332 CDD:349865 6/21 (29%)
TM4 helix 430..452 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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