Protein Alignment nAChRalpha6 and acr-18

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_506868.2
• Gene: acr-18 / 191604
• WormBaseID: WBGene00000057
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 142/522 - (27%)
• Similarity: 242/522 - (46%)
• Gaps: 83/522 - (15%)

  Fly    31 KRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNE 95
            :.|..||...|....|||.||||.|:|:....|:||:.|||::||:....||.|.|.|..|.|:.
 Worm    31 RNLYEHLFLDYVKEIRPVRNESESLKVEIKFWLKQILKVDERDQIVNIYCWLELYWIDETLTWDP 95

  Fly    96 TEYGGVKDLRITPNKLWKPDVLMYNSADEGF-DGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            .::|.:..:.:..:|:||||||:||:|:... :....||.:|.:.|..:.....|...:|.:::.
 Worm    96 KKFGNLSRIHVPAHKIWKPDVLVYNNANMNVEENEMETNAIVDNTGRVMLFRSMITDISCNLNLQ 160

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPY 224
            .||||.|.|.:.|.||:.||::|||....:. .:|..:|.|.||.|.....|....:|.|||.|:
 Worm   161 QFPFDQQICFVTFASWSMDGSKLDLSATPKT-DNLELYIRNTEWGLTDFRVKIYQKIYDCCPHPF 224

  Fly   225 VDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP----PDSGEKLTLGVTILLSLTVFLNL 285
            .|:|:.:.:||...||.|:|::|...|:.:.::||..|    .::.||::||||.|||:.:.:.:
 Worm   225 PDVTYFMVLRRSPSYYIFSLVIPSAFITVVTIVGFFTPHSTTGENTEKVSLGVTALLSMAIIMMM 289

  Fly   286 VAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVV 350
            |::.:|.||:.:|||                             |.|:..::|::..:...|.:.
 Worm   290 VSDEVPATSEVIPLI-----------------------------GKYYIGLIFLIFMAAFTTTLT 325

  Fly   351 LNYHHRTADIHEMPPWIKSVFL------QWLPWILRMGRPGRKITRKTILLSNRMKELELKERS- 408
            |:|..|.....|:.|.::..|.      ..:.|......|      |.:|.|:..|:.......
 Worm   326 LSYQMRGNSGQEVDPRVRDFFFYQIAANPCISWAFSFQLP------KKLLRSDHRKQSFFFTNGA 384

  Fly   409 ------SKSLL------ANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLH 461
                  ||..|      |:::.:::     |:|.    ||..||..........|.:..:...:.
 Worm   385 AHVNGYSKGALHPNTPPAHIVKMEE-----ITGG----GSVKSFVMSQESAATSTLLTSSLMKIK 440

  Fly   462 LILKELQFITARMRKADDEAE-----LIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA-PHI 520
            ::|.::        ||...||     :..:|:....::||..:..:.|.||...:.:|.|. |.|
 Worm   441 VVLDDM--------KASIHAERELKRIKFEWQQVTRLIDRCIMFSYILITIAFAMVMLASRDPPI 497

  Fly   521 IV 522
            ::
 Worm   498 VL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	139/514 (27%)
		LGIC_ECD_nAChR	55..236	CDD:349798	63/181 (35%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
acr-18	NP_506868.2	LGIC_ECD_nAChR	55..235	CDD:349798	62/180 (34%)
		Cys-loop	155..169	CDD:349798	6/13 (46%)
		LGIC_TM_cation	238..>327	CDD:349853	29/117 (25%)
		TM1 helix	238..262	CDD:349853	8/23 (35%)
		Neur_chan_memb	244..486	CDD:460753	60/293 (20%)
		TM2 helix	274..295	CDD:349853	8/20 (40%)
		TM3 helix	306..327	CDD:349853	3/20 (15%)