DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and acr-17

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001023961.1	Gene:	acr-17 / 191603	WormBaseID:	WBGene00000056	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	148/551 - (26%)
Similarity:	233/551 - (42%)	Gaps:	158/551 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKRLLNHLLSTYNTLERPVANESE-PLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRW 93
            :|:|:.:|...|:...|||.:||. |..|...|..:||..|.|.:||:|...|:...|.|..|.|
Worm    24 QKQLIKYLFRDYHKELRPVKDESSGPTNVTVQLYFKQIQKVHENDQIITLYCWIEEYWQDEFLTW 88

  Fly    94 NETEYGGVKDLRITPNKLWKPDVLMYNSADEGF-DGTYHTNIVVKHNGSCLYVPPGIFKSTCKID 157
            |.:::|.:|.|.:....:||||:|:||:|:... :....||:.::|.|........|...||.:.
Worm    89 NPSDFGNIKSLHVPSEMIWKPDLLVYNNANMNIKENEMQTNVQIEHTGKISLFRAIITDITCDLQ 153

  Fly   158 ITWFPFDDQHCEMKFGSWTYDGNQLDL------------VLNSEDGGDLSDFITNGEWYLLAMPG 210
            :..||:|.|.|.:...||:|||:|:.|            :.|:.:...|:.:|.|.||.|:....
Worm   154 MEKFPYDQQICFIMLASWSYDGSQIMLNTAEQPTEAPLDIKNTTNLAILNHYIPNMEWKLVDFRY 218

  Fly   211 KKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS----GEKLTL 271
            :.|...|.|||.||.||::...|:|...||.|.||:|...|:.:.::||..|..|    .||::|
Worm   219 RNNLKYYDCCPNPYPDISYFFAIKRNPSYYLFTLIIPSAFITIVTVIGFFTPHSSTGENTEKVSL 283

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            |||.||||.:.|.:|::.:|.||::|||:|       ..::.|:         .|..|.||  |.
Worm   284 GVTALLSLAIILMMVSDKLPATSNSVPLLG-------QYYIGLI---------FIMFLATY--CT 330

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITR--KTILLSNRM 399
            .|.:.                                    |...|..||.|||  ::.|||.||
Worm   331 TFTLG------------------------------------IQMQGNAGRPITRRLRSFLLSIRM 359

  Fly   400 -----------KEL------------------ELKERSSKSLL---ANVLDIDDDFRHTISGS-- 430
                       :||                  |||::.:...:   ..:|..|:. :|..:.|
Worm   360 NRNSFVQWFFGRELMNTQESIKMRLKKYDKLSELKKKFANGFVQFQQKLLKTDEP-KHNKTASLI 423

  Fly   431 -QTAIGSS------------------ASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRK 476
             |.:|.||                  .|..:..|.:||              ||       |:||
Worm   424 EQESIDSSKLLDPAMYNVVVDVLSSVQSIRQDLTSQEH--------------LK-------RIRK 467

  Fly   477 ADDEAELIGDWKFAAMVVDRFCLIVFTLFTI 507
                     :|:..|.::::..:.:|.:.|:
Worm   468 ---------EWQMLARMLEKIIMWIFIISTV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	148/551 (27%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	62/193 (32%)
acr-17	NP_001023961.1	LIC	23..491	CDD:273305	148/551 (27%)
		Neur_chan_LBD	24..245	CDD:280998	73/220 (33%)
		Neur_chan_memb	252..491	CDD:280999	72/323 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010