DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and acr-15

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_505206.2	Gene:	acr-15 / 191602	WormBaseID:	WBGene00000054	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	193/522 - (36%)
Similarity:	284/522 - (54%)	Gaps:	63/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILT 77
            :||.||.:|.:....|.|.||:|.|:|.|...|||..:.|:|:.|..|:.|||||::.||.:.|.
Worm     5 ILLHFLLLITQLNGSPAEVRLINDLMSGYVREERPTLDSSKPVVVSLGVFLQQIINLSEKEEQLE 69

  Fly    78 TNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSC 142
            .||||..:|.|.||||..|.|..|.|||..|:.||.||:|:|||.|..||.:|..|:|..|.|:.
Worm    70 VNAWLKFQWRDENLRWEPTAYENVTDLRHPPDALWTPDILLYNSVDSEFDSSYKVNLVNYHTGNI 134

  Fly   143 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG-DLSDFITNGEWYLL 206
            .::||||||.:||:||.|||||:|.|..|||||||..:::.|    |.|. |.|:||.||||.::
Worm   135 NWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTYTRDKIQL----EKGDFDFSEFIPNGEWIII 195

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            ..........|.||||.|.|||||:.:|||||||.||||.|.:|...:.:||||:.|::.||:.|
Worm   196 DYRTNITVKQYECCPEQYEDITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSPETCEKVGL 260

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            .:::.|::.:||                   ||:..||          ||.|:|:||||.:|:..
Worm   261 QISVSLAICIFL-------------------TIMSELT----------PQTSEAVPLLGVFFHTC 296

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHE-MPPWIKSVFLQWLPWILRMGRPGRKITRKTILLS---- 396
            .|:...:...||.|.::|.|...:|| |..|::.:.|:|.||:|||..|.|:...:|:..|
Worm   297 NFISVLATSFTVYVQSFHFRNQHVHERMDFWMRFILLEWSPWLLRMKMPDRENNFQTLTESWKGR 361

  Fly   397 NRMKEL-----ELKERSSKSLLANVLDIDDDFRHTI-SGSQTAIGSSASFGRPTTVEE--HHTAI 453
            ||.:.:     |..:.....:.:..:.:.|:|...| ...|..|.......|...:::  .|..:
Worm   362 NRRESMARTAFEYADGPVTQIHSMGIMLKDNFEELIYQVKQEKIADEKGIERLRVLQKIYDHVKM 426

  Fly   454 GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAP 518
            ...|.|                ..|:::.:..:|:|||:||||.||:.|:|..::.::.:.|.||
Worm   427 IREHDD----------------DNDEDSRVALEWRFAAIVVDRLCLLAFSLLIVVVSIIIALRAP 475

  Fly   519 HI 520
            ::
Worm   476 YL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	191/517 (37%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	90/181 (50%)
acr-15	NP_505206.2	LIC	19..470	CDD:273305	185/499 (37%)
		Neur_chan_LBD	22..226	CDD:280998	103/207 (50%)
		Neur_chan_memb	233..470	CDD:280999	74/281 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880