Protein Alignment nAChRalpha6 and acr-15

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_505206.2
• Gene: acr-15 / 191602
• WormBaseID: WBGene00000054
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 193/522 - (36%)
• Similarity: 284/522 - (54%)
• Gaps: 63/522 - (12%)

  Fly    13 VLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILT 77
            :||.||.:|.:....|.|.||:|.|:|.|...|||..:.|:|:.|..|:.|||||::.||.:.|.
 Worm     5 ILLHFLLLITQLNGSPAEVRLINDLMSGYVREERPTLDSSKPVVVSLGVFLQQIINLSEKEEQLE 69

  Fly    78 TNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSC 142
            .||||..:|.|.||||..|.|..|.|||..|:.||.||:|:|||.|..||.:|..|:|..|.|:.
 Worm    70 VNAWLKFQWRDENLRWEPTAYENVTDLRHPPDALWTPDILLYNSVDSEFDSSYKVNLVNYHTGNI 134

  Fly   143 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG-DLSDFITNGEWYLL 206
            .::||||||.:||:||.|||||:|.|..|||||||..:::.|    |.|. |.|:||.||||.::
 Worm   135 NWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTYTRDKIQL----EKGDFDFSEFIPNGEWIII 195

  Fly   207 AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTL 271
            ..........|.||||.|.|||||:.:|||||||.||||.|.:|...:.:||||:.|::.||:.|
 Worm   196 DYRTNITVKQYECCPEQYEDITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSPETCEKVGL 260

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCI 336
            .:::.|::.:||                   ||:..||          ||.|:|:||||.:|:..
 Worm   261 QISVSLAICIFL-------------------TIMSELT----------PQTSEAVPLLGVFFHTC 296

  Fly   337 MFMVASSVVLTVVVLNYHHRTADIHE-MPPWIKSVFLQWLPWILRMGRPGRKITRKTILLS---- 396
            .|:...:...||.|.::|.|...:|| |..|::.:.|:|.||:|||..|.|:...:|:..|
 Worm   297 NFISVLATSFTVYVQSFHFRNQHVHERMDFWMRFILLEWSPWLLRMKMPDRENNFQTLTESWKGR 361

  Fly   397 NRMKEL-----ELKERSSKSLLANVLDIDDDFRHTI-SGSQTAIGSSASFGRPTTVEE--HHTAI 453
            ||.:.:     |..:.....:.:..:.:.|:|...| ...|..|.......|...:::  .|..:
 Worm   362 NRRESMARTAFEYADGPVTQIHSMGIMLKDNFEELIYQVKQEKIADEKGIERLRVLQKIYDHVKM 426

  Fly   454 GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAP 518
            ...|.|                ..|:::.:..:|:|||:||||.||:.|:|..::.::.:.|.||
 Worm   427 IREHDD----------------DNDEDSRVALEWRFAAIVVDRLCLLAFSLLIVVVSIIIALRAP 475

  Fly   519 HI 520
            ::
 Worm   476 YL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	191/517 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	90/181 (50%)
		Cys-loop	154..168	CDD:349798	10/13 (77%)
acr-15	NP_505206.2	LIC	19..470	CDD:455710	185/499 (37%)
		LGIC_ECD_nAChR	47..225	CDD:349798	90/181 (50%)
		Cys-loop	146..160	CDD:349798	10/13 (77%)