DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and acr-14

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_495716.1	Gene:	acr-14 / 191601	WormBaseID:	WBGene00000053	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	199/549 - (36%)
Similarity:	291/549 - (53%)	Gaps:	88/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            |...|:||.|...:|.|..   |.|||.:|...|::.||||.|.|.||:||....|.||:|||||
Worm     2 SFVFFILLTFYIQVKGSVD---EYRLLQYLKENYDSFERPVENSSAPLDVKVRFLLNQIMDVDEK 63

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPN-----KLWKPDVLMYNSADEGFDGTYHT 132
            ||:::..|:::..||||.|.|:...:||::|:|.:.:     |||:||||::||..|.||.||.:
Worm    64 NQVMSILAYMDYHWNDYKLTWDPKLFGGIRDVRFSGDDDASFKLWRPDVLLFNSVSESFDSTYSS 128

  Fly   133 NIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGN--QLDLVLNS------- 188
            ..:|..||.....|||||:..|:||:|::|||.|.|.:|.|||||:|.  .||.:|..
Worm   129 RFIVSSNGDVQQNPPGIFRFVCQIDVTYYPFDKQTCFLKLGSWTYNGQYINLDFLLTQIIGLHGI 193

  Fly   189 ------------------EDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRR 235
                              .:..||..::.||||.|...|||:  :|.....:.|.::.|.|.|||
Worm   194 PIVVEPERSSTNYASYFVNESIDLQVYLQNGEWDLEGTPGKR--VVQKFGTDEYHELYFYIHIRR 256

  Fly   236 RTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLI 300
            |||.|..|||:|.::||.|.:||||||||:.||:||..|:|||:..||.:|:.:.|
Worm   257 RTLAYGINLIIPSLVISMMTILGFTLPPDACEKITLETTVLLSVIFFLQMVSSTSP--------- 312

  Fly   301 GVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPP 365
                               || |.::|:|..:|:|.:.:||.|.|.||:.|:.|||..:.|||.|
Worm   313 -------------------PQ-SQSVPILAAFFSCCLMLVACSCVFTVLTLSLHHRKPETHEMSP 357

  Fly   366 WIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGS 430
            .::.:|:.|||:||.|.:|....|.|..:|.   |.:....|.|...:.|:..:          |
Worm   358 TMRKIFIDWLPYILCMCKPDHPKTPKPKVLG---KSIAPIHRLSTIPMLNLPRV----------S 409

  Fly   431 QTAIGSSASF---GRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAM 492
            ||.......|   ..|..::  :|:..|  .:|.:|.::::.:..::.:...|..|..:|:||||
Worm   410 QTTFPDKNVFVYHEVPAVIK--NTSRIC--AELLIIERDIEKMLDKIEEDTKEDMLRSEWRFAAM 470

  Fly   493 VVDRFCLIVFTLFTIIATVTVLLSAPHII 521
            .|||.||.||:.|  |..:|..|..|||:
Worm   471 AVDRLCLYVFSAF--ITMITCGLIVPHIL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	195/540 (36%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	81/212 (38%)
acr-14	NP_495716.1	LIC	21..483	CDD:273305	185/509 (36%)
		Neur_chan_LBD	21..258	CDD:280998	95/238 (40%)
		Neur_chan_memb	265..491	CDD:280999	88/273 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880