DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and lev-8

DIOPT Version :9

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_509932.2 Gene:lev-8 / 191600 WormBaseID:WBGene00002975 Length:531 Species:Caenorhabditis elegans


Alignment Length:574 Identity:166/574 - (28%)
Similarity:279/574 - (48%) Gaps:133/574 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LPASLS-LFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIID 68
            :|..:| :|:|:||:..|.......|..:||.:||:.||...|||.|.|:.|:||||..|.::||
 Worm     3 IPQRISHIFLLVIFILHIVTINANKHVSQLLENLLTDYNKAVRPVHNASDALKVKFGANLCRLID 67

  Fly    69 VDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTN 133
            |||.||:|||:.||.::|.|..|.||.|::|||:.:.|..:::|.||:::||:|    ||..|..
 Worm    68 VDEVNQVLTTSLWLEMQWYDKKLTWNPTDWGGVEYIHIPSDQIWIPDIVLYNNA----DGEPHIT 128

  Fly   134 IV----VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL---------- 184
            |.    :.|:|..::.||.|:||.|.|:|.:||:|.|.||||||.|:.||..|||          
 Worm   129 ITSLAKIDHHGRVVWQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQIPVDVDDI 193

  Fly   185 --VLNSEDGGD---------LSDFITNGEWYLLAMPGKKNTIVY-ACCPEP-YVDITFTIQIRRR 236
              |...:||.:         ||.:..:.||.||:....:...:| .||.:. |:||.:.|.|||:
 Worm   194 PQVKRQDDGVEFLYLEKGLGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRK 258

  Fly   237 TLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIG 301
            .:::...|.:||:||:::....|.:.|:. .|:|..:::|::.:||..::.:.:|.||.::.|||
 Worm   259 AIFFTVTLTIPCMLIANVTPFVFLILPNE-HKMTYSISVLVAFSVFYLVLIDLIPPTSLSLSLIG 322

  Fly   302 VTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPW 366
            :.:|.:|                             .||:.|::|:||.:|.:.:.|....|..|
 Worm   323 IYLLFTL-----------------------------LMVSVSIILSVVTINMYRKQAFSSGMSHW 358

  Fly   367 IKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTI---S 428
            .:.:|:|.||.:|                  |:|.||                     ||:   .
 Worm   359 QRWLFVQRLPKLL------------------RLKTLE---------------------HTLGPDE 384

  Fly   429 GSQT------AIGSSASFGRPTTVEEHHTAI--------------------GCNHKDLHLILK-- 465
            ||:|      ::..:||..:.|....:::.:                    .|...:|.|..|  
 Worm   385 GSETTTPRTGSVSVTASVTQRTLNPNNNSPVFPPQRLRLLSLVQMDEALKQRCAADNLDLFRKIA 449

  Fly   466 -ELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAP 518
             .|:.|:|.......|.::..:|:..::|:||..||:|...::.|.:..:.::|
 Worm   450 GHLKIISAHFHNQQMEGKITEEWQLMSLVIDRIFLILFLAVSMAANIMFVYNSP 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 163/564 (29%)
LGIC_ECD_nAChR 55..236 CDD:349798 82/207 (40%)
lev-8NP_509932.2 LIC 10..499 CDD:273305 163/561 (29%)
Neur_chan_LBD 30..258 CDD:280998 93/231 (40%)
Neur_chan_memb 268..497 CDD:280999 62/297 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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