Protein Alignment nAChRalpha6 and acr-10

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_508692.3
• Gene: acr-10 / 191598
• WormBaseID: WBGene00000049
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 602
• Identity: 199/602 - (33%)
• Similarity: 289/602 - (48%)
• Gaps: 141/602 - (23%)

  Fly     9 LSLFVLLIF----LAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDV 69
            :..|||.:|    |.||:..| ...|.:|...:|..|..|.|||......|:|...:.||||:::
 Worm     3 IRFFVLCLFFILSLIIIESEC-SKAENKLYRDILQGYLKLARPVRYPRNVLKVHMKVFLQQILNL 66

  Fly    70 DEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRIT--PNKLWKPDVLMYNSADEGFDGTYHT 132
            |.:|||:..||||...|.||.|:|:..:|..:..:|..  .|::|:||:|:||||.|.||.::.:
 Worm    67 DGQNQIIEVNAWLKYVWMDYRLQWDPLQYDNITSIRFAGGENQIWRPDILLYNSASEDFDSSFKS 131

  Fly   133 NIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL-VLNSEDGG---- 192
            |.||.:.|...::|||||:::||:|||:||||||.|.:|||||||.|..||| ::..||..
 Worm   132 NEVVYNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSIIAEEDDSELSI 196

  Fly   193 DLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALL 257
            |||.:..:|||:|...|..|:....:||.|||..:||.:.:|||||:|.||:|:|.:|||.|.|:
 Worm   197 DLSTYTPSGEWHLTKAPAVKDVKYNSCCKEPYSTVTFYMFLRRRTLFYLFNIILPSLLISIMTLM 261

  Fly   258 GFTLPP-DSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQ 321
            ||.||. |..||:....|||||:..|:.:|:|..|.||::|
 Worm   262 GFCLPAHDMSEKIGYQTTILLSICFFVTIVSEMTPPTSESV------------------------ 302

  Fly   322 VSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGR 386
                 ||||.:|:.:..:.:.|...|:.|||:.:|......|.|....|||.|:||:|.|.|||
 Worm   303 -----PLLGMFFSSLTLISSVSTAFTITVLNFRYRQVQNIHMHPIFYKVFLIWIPWLLLMKRPG- 361

  Fly   387 KITRKTILLSNRMKELELKERSSKSLLANVLDIDDD--------FRHTISGSQTAIGSSASF--- 440
                  :....|...::.:|..|      ..|..||        |.:::|     |.|:.:.
 Worm   362 ------VFYKKRRATVQAREEIS------FFDNGDDDCCPKPPEFDYSLS-----IDSADTLPLP 409

  Fly   441 GRPTTVEEHHTAIGCNHKDLHL-------ILKE----------------------LQF------- 469
            .||..:.:...::...|  |||       |||.                      .||
 Worm   410 PRPKPLLKKMHSVPAEH--LHLDRKVGDGILKSQRRPLVLTKNVNKSHSLRSRRFTQFEKYIKKC 472

  Fly   470 ------------------ITARMRKADDEAELIG--------------DWKFAAMVVDRFCLIVF 502
                              |....|:.|:..:|:.              |||||||.:||.||::.
 Worm   473 IDDAKLRKNSTYSTYSMMIITYYRQIDEMLKLLNRRLDKQRKYLFKQEDWKFAAMALDRLCLLLI 537

  Fly   503 TLFTIIATVTVLLSAPH 519
            ||..::....::||.||
 Worm   538 TLLIVMCLFGMILSTPH 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	196/596 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	84/187 (45%)
acr-10	NP_508692.3	Neur_chan_LBD	27..241	CDD:280998	93/213 (44%)
		Neur_chan_memb	248..>361	CDD:280999	48/141 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880