Protein Alignment nAChRalpha6 and acr-5

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 138/530 - (26%)
• Similarity: 228/530 - (43%)
• Gaps: 97/530 - (18%)

  Fly    30 EKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLR 92
            ::||:..||  :.|.....|..:.:.|..|...::|.||:||||..|.:..|.|:...|.|..|.
 Worm   104 QRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFLD 168

  Fly    93 WNETEYGGVKDLRITPNKLWKPDVLMYNSAD------EGFDG----TYHTNIVVKHNGSCLYVP- 146
            ||..:||.:....:..:::|.||..:|||.:      |....    |.|.|  .|.:|:.:.:.
 Worm   169 WNPVDYGMINRTIVPYHQIWIPDTYLYNSEELEQKKTESLMNAQLETGHWN--QKKDGAKVQLMF 231

  Fly   147 PGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL-VLNSEDGGDLSDFITNGEWYLLAMPG 210
            |.|:|.:|::|:.|||:|.|:|.....|||:|...:|. .|:|.  .:|.:...|.||.:::...
 Worm   232 PAIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLSST--VNLGNMARNDEWEVISFEF 294

  Fly   211 KKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSG----EKLTL 271
            .:....:.||..|:|.:...:.|||:.|||..||:||..:|:.:|:.||..|..|.    |||.|
 Worm   295 VRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFFTPTSSSSERDEKLYL 359

  Fly   272 GVTILLSLTVFLNLVAESMPTTSDAVPL-----IGVTILLSLTVFLNLVAETL-------PQVSD 324
            |:..||:::|.:.:|...||:||..|||     ||:.:::.:..||......:       ..:||
 Worm   360 GINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGVLAIHGQKHYNKPISD 424

  Fly   325 AIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKIT 389
            .|..| .|...:.|.:.|                     ||  .|:...|..:.:...:  |..|
 Worm   425 RIRKL-IYNPVVEFFILS---------------------PP--TSLIDLWTEFGVISEQ--RHST 463

  Fly   390 RKTILLSNRMKELELKERSSK-----SLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEH 449
            ....||...|..:....|:..     |:.:.:.|:...:.:|              .|..|:...
 Worm   464 HLDPLLLQHMDPISHTTRADPQHFFGSISSQMCDLQSTYSYT--------------ARLATITRQ 514

  Fly   450 HTAIGCNHKDLHLILKELQFITARMRKADDEAELIG----------DWKFAAMVVDRFCLIVFTL 504
            :|.        |..:|.|:....||.....:|..:.          :|:|.|.|:||..|.:|..
 Worm   515 YTQ--------HAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSLEWEFLANVLDRILLTIFCG 571

  Fly   505 FTIIATVTVL 514
            ||....:.::
 Worm   572 FTFAVFIILI 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	138/530 (26%)
		LGIC_ECD_nAChR	55..236	CDD:349798	58/192 (30%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	138/528 (26%)
		Neur_chan_LBD	104..321	CDD:397192	66/220 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910