DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and lgc-19

DIOPT Version :10

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_502905.2 Gene:lgc-19 / 190895 WormBaseID:WBGene00013655 Length:400 Species:Caenorhabditis elegans


Alignment Length:307 Identity:75/307 - (24%)
Similarity:152/307 - (49%) Gaps:23/307 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 EKRLLNHLLSTYN----------TLERPVANESE-PLEVKFGLTLQ--QIIDVDEKNQILTTNAW 81
            ::.|..|:...|:          .::.|:..::| |....:.:.|.  ::::|.|..:.::....
 Worm    34 QRNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKISVVME 98

  Fly    82 LNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSAD-EGFDGTYHTNIVVKHNGSCL-Y 144
            :...|.|..|.||.:.:.....:.:..:|:|.|.:.::...| ..|....:..|.:::.|... |
 Worm    99 IMEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRLICIENTGFIWDY 163

  Fly   145 VPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNS--EDGGDLSDFIT--NGEWYL 205
            |...: .:.|::|::.||||.|.|:::|....:...|:| :||.  |:..|...|.|  |.||.|
 Worm   164 VSVRV-SANCEMDVSRFPFDTQICQIRFCLPIFYRVQVD-ILNEIYEEIMDERIFKTMGNSEWKL 226

  Fly   206 LAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLG-FTLPPDSGEKL 269
            |.:..:...:||...........|.|.|||..|||.:.::.|..:|:.::::| |....|...:|
 Worm   227 LNLTNRVEALVYNDNMGTMDLAIFEITIRRNPLYYIYMIVFPSFIINFVSIVGVFLNGADKMSRL 291

  Fly   270 TLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVA 316
            .:|:|.::::|..|.::|:.:|.|.: :||:|:.|:::|.:.|..:|
 Worm   292 NVGLTNIMTMTFILGVMADKIPRTGN-IPLLGIYIIINLVIMLIAIA 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:455710 75/307 (24%)
LGIC_ECD_nAChR 55..236 CDD:349798 45/188 (24%)
Cys-loop 154..168 CDD:349798 7/13 (54%)
lgc-19NP_502905.2 LGIC_ECD_cation 75..257 CDD:349790 45/183 (25%)
Cys-loop 172..186 CDD:349790 7/13 (54%)
LGIC_TM_cation 259..>346 CDD:349853 23/80 (29%)
TM1 helix 259..284 CDD:349853 7/24 (29%)
TM2 helix 292..313 CDD:349853 5/20 (25%)
TM3 helix 323..346 CDD:349853 4/15 (27%)

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