Protein Alignment nAChRalpha6 and pbo-5

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 422
• Identity: 105/422 - (24%)
• Similarity: 184/422 - (43%)
• Gaps: 96/422 - (22%)

  Fly    31 KRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNE 95
            |||..:|||.:|....|    ...|.|::.|.|..|:.:||..|.:|...:::..|.|.:|.|:.
 Worm    68 KRLTEYLLSRHNLNAPP----DGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWDP 128

  Fly    96 TEYGGVKDLRITPNKLWKPDVLMYNS------ADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTC 154
            ..:||:....|..:|:|.||::::|.      |.|...........:.:||:.:...|.:...:|
 Worm   129 ALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVSC 193

  Fly   155 KIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYAC 219
            :|:|..||.|||.|.::..||.|  .|..:.|::.....|..:..|.||:||.:...:
 Worm   194 EINIRHFPLDDQRCAIEIASWAY--GQEKIRLHAHTDHSLEHYKRNEEWHLLNLNVSE------- 249

  Fly   220 CPEPY-------VDITFTIQIRRRTLYYFFNLIVPCVLISSMALLG----FTLPPDSGEKLTLGV 273
              |.|       .::.|.|.::||.|:|...|..|..::.:::::|    |:...:..|:.||||
 Worm   250 --EKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFTLGV 312

  Fly   274 TILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMF 338
            |.:|::.|                        |||     :|:|.:|..|..:|||..||...|.
 Worm   313 TAILTMAV------------------------LSL-----VVSEKVPHSSTHVPLLVAYFLFNMV 348

  Fly   339 MVASSVVLTVVVLNYHHRTADIHEMPP--WIKSVFLQWLP--------------------WILRM 381
            :|:.:.:.|.:|:.. ||.....:.|.  |::...|:  |                    .::..
 Worm   349 IVSIAAMTTGIVMKV-HRLGRYGDEPSDFWMRCFLLK--PVFRTSNRRKYRMNPEEPTQVILVSE 410

  Fly   382 GRPGRKITRKT----------ILLSNRMKELE 403
            .:.|..:|:|:          |:||:|::.||
 Worm   411 AKNGEVLTKKSTELNGTVVKEIMLSSRLEALE 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	105/422 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	50/193 (26%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
pbo-5	NP_001024240.1	LGIC_ECD_cation	88..271	CDD:349790	50/193 (26%)
		LIC	90..500	CDD:455710	96/396 (24%)
		Cys-loop	193..207	CDD:349790	8/13 (62%)