Protein Alignment nAChRalpha6 and lgc-1

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 392
• Identity: 82/392 - (20%)
• Similarity: 160/392 - (40%)
• Gaps: 102/392 - (26%)

  Fly    30 EKRLLNHLLSTYN-------------------TLERPVANESEPLEVKFGLTLQQIIDVDEKNQI 75
            :|||.:.|...|:                   |:..|:.      |:|..:.:.:::||.|..:.
 Worm    16 QKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPIT------ELKLTMAMLKLVDVVEVEEK 74

  Fly    76 LTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGF---DGTYHTNIVVK 137
            :|.......||.|..|:||..||||:..:.:....:|.|:|.:.::.:..|   |....| ..:.
 Worm    75 VTFLFDYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTIADAHEVKFFESDDAPRT-AWIN 138

  Fly   138 HNGSCLYVPPGIFKST-----CKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDF 197
            :||:     .|.:.||     |::|:..||.|...|.:.....||..::..:..:.|........
 Worm   139 YNGT-----TGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIKSDMEPLPKPLSQ 198

  Fly   198 ITNGEWYLLAMPGKKNTIVYACCPEPYVDIT-------------FTIQIRRRTLYYFFNLIVPCV 249
            :.||||.:                 .|:.:.             |..:|.|...:|...::||..
 Worm   199 LGNGEWKV-----------------TYIGVAEEIGNGNFSAVQRFVARIERNPGFYVTLVMVPAF 246

  Fly   250 LISSMALLGFTLPPDS-GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLN 313
            .|:.::::...|..:: |||:|:|:|.::::|..|.::|:.:|.|. .:||:.:.:::.|
 Worm   247 FINFLSIIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTK-RIPLLAIYVIVGL----- 305

  Fly   314 LVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYH--HRTADIHEMPPWIKSVFLQWLP 376
                                  ::.|.:..||||:.::..|  .|.....|.|  :::.|.:|..
 Worm   306 ----------------------VIVMASIGVVLTLPLIRNHLKKRQKGKEEKP--VETRFSKWFG 346

  Fly   377 WI 378
            |:
 Worm   347 WL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	82/392 (21%)
		LGIC_ECD_nAChR	55..236	CDD:349798	43/201 (21%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	64/301 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010