Protein Alignment nAChRalpha6 and lgc-18

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510029.3
• Gene: lgc-18 / 187977
• WormBaseID: WBGene00011360
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 417
• Identity: 99/417 - (23%)
• Similarity: 178/417 - (42%)
• Gaps: 120/417 - (28%)

  Fly    14 LLIFLAIIK--------ESCQGP-------HEKRLLNHLLSTYNTLERPVANESEPLE------- 56
            :||| |||:        ||...|       ::.:|:..:.:.|:....||..:.:|.:
 Worm     4 VLIF-AIIEITTCFYQNESLYVPEWNNFLENQVKLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPL 67

  Fly    57 --VKFGLT-------LQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLW 112
              .:|..|       |.::|:.:||..::...|..   |.|..:.|:.:.||.:|.|.:..:|:|
 Worm    68 APKRFNYTVSLYYLKLVEVIEPEEKVSVVLEMAEY---WYDPRIAWDSSLYGDIKMLHMRQDKVW 129

  Fly   113 KPDVLMYNSAD--------------EGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPF 163
            .|.:.::...|              |....|| |.:.||            ....|.:|::.||:
 Worm   130 SPTLSLFRINDIADFRDPDFRMVCVENTGHTY-TTLSVK------------ISLNCPLDVSMFPY 181

  Fly   164 DDQHCEMKFG------------SWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIV 216
            |.|.|.::|.            |..|:|     :|||    .:.:.:.|.||.|..:......:.
 Worm   182 DSQTCRIQFNMPLFFMQQVEMFSQIYEG-----ILNS----TVWEKMGNSEWELANLTHSVELLS 237

  Fly   217 YACCPEPYVDI---TFTIQIRRRTLYYFFNLIVPCVLISSMALLG-FTLPPDSGEKLTLGVTILL 277
            |.   :...|:   ||.|:|||..:||.:.:|.|..:|::::::| |....|...||.:|:|.::
 Worm   238 YG---DGLGDMQLATFEIRIRRNPMYYIYMIIFPSFIINALSIIGVFLKKTDKMSKLNVGLTNIM 299

  Fly   278 SLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAET--LPQVSD-AIP------------ 327
            ::|..|.::|:.:|.|. ::||:|:.|:::|.:.:..|..|  |.::.. |||
 Worm   300 TMTFILGVMADKIPKTG-SIPLLGIYIIVNLFIMIVAVGLTIVLAEIQKCAIPKLRKNKSKMNQK 363

  Fly   328 ---LLG-----------TYFNCIMFMV 340
               :||           ..||..:|||
 Worm   364 LEYVLGEPLETICMVILEIFNTAIFMV 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	99/417 (24%)
		LGIC_ECD_nAChR	55..236	CDD:349798	49/225 (22%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	48/209 (23%)
		Cys-loop	172..186	CDD:349790	6/13 (46%)
		LGIC_TM_cation	259..>341	CDD:349853	24/82 (29%)
		TM1 helix	259..284	CDD:349853	7/24 (29%)
		TM2 helix	292..313	CDD:349853	5/20 (25%)
		TM3 helix	323..341	CDD:349853	4/17 (24%)