Protein Alignment nAChRalpha6 and lgc-17

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510028.2
• Gene: lgc-17 / 187976
• WormBaseID: WBGene00011359
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 376
• Identity: 82/376 - (21%)
• Similarity: 159/376 - (42%)
• Gaps: 98/376 - (26%)

  Fly    29 HEKRLLNHLLSTYN-TLE---------RPVANESEPLEVKFGLTL----QQIIDVDEKNQILTTN 79
            |:..|...|.:.|: |:.         .|..|.:..:: ::..|:    .::::|.|..:.::..
 Worm    35 HQDNLTRDLFANYDPTISSVYSSSFDYEPSHNHTRTVD-RWNYTILLYYLKLVEVQEPEEKVSVV 98

  Fly    80 AWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKP----------------DVLMYNSADEGFDG 128
            ..|..:|.|..|.||.:.|..:..:.:...|:|.|                |..:.:..|.|:..
 Worm    99 LELVEQWYDPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAFGVNEIIDFRDQDFRIVSIDDIGYIQ 163

  Fly   129 TYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGD 193
            .|.:..|               .|.|.:|::.||||.|.|::.|....::..|:. :||....|.
 Worm   164 DYLSVRV---------------SSNCPMDVSRFPFDSQTCQICFCLPIFNIRQVK-ILNEIYEGI 212

  Fly   194 LSDFIT----NGEWYLLAMPGKKNTIVYACCPEPY--VDI-TFTIQIRRRTLYYFFNLIVPCVLI 251
            |.:.|.    |.||.::::..:...:.|   .:.|  :|: .|.|.|||..|||.:.::.|..:|
 Worm   213 LQEKIIKTMGNSEWKVVSLTNRVEQLKY---DDDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVI 274

  Fly   252 SSMALLG-FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLV 315
            :.::::| |....|...||.:|:|.::::|..|.::|:.:|.|. ::||:|:.|:::|.:.:
 Worm   275 NGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLLIMI--- 335

  Fly   316 AETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPW 366
                                        :.:|||||        |.|:..|
 Worm   336 ----------------------------IAITVVVL--------ITELRQW 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	82/376 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	44/207 (21%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	44/200 (22%)
		LGIC_TM	261..>317	CDD:365787	16/55 (29%)
		TM1 helix	261..286	CDD:349850	7/24 (29%)
		TM2 helix	294..315	CDD:349850	5/20 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010