Protein Alignment nAChRalpha6 and lgc-16

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 83/371 - (22%)
• Similarity: 159/371 - (42%)
• Gaps: 90/371 - (24%)

  Fly    30 EKRLLNHLLSTYN-TLERPVAN--ESEPL----------EVKFGLTLQQIIDVDEKNQILTTNAW 81
            ::.|.|.|.:.|: |:....|:  :.|||          .....|...::::|.|..:.::....
 Worm    36 QENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLE 100

  Fly    82 LNLEWNDYNLRWNETEYGGVKDLRITPNKLWKP--------DVLMYNSAD-----EGFDGTYHTN 133
            |...|.|..|.||.:.|..|..:.....|:|.|        :::.:...|     ..|.|..:..
 Worm   101 LVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDY 165

  Fly   134 IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFI 198
            :.|:            ..:.|.:|::.||||.|.|:::|....::..|:. :||....|.|.:.|
 Worm   166 LSVR------------VSANCPMDVSRFPFDSQTCQIRFCLPIFNIRQVK-ILNEIYEGILQEKI 217

  Fly   199 T----NGEWYLLAMPGKKNTIVYACCPEPY--VDI-TFTIQIRRRTLYYFFNLIVPCVLISSMAL 256
            .    |.||.::::..:...:.|   .:.|  :|: .|.|.|||..|||.:.::.|..:|:.:::
 Worm   218 IKTMGNSEWKVVSLTNRVEQLKY---DDDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVINGISI 279

  Fly   257 LG-FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLP 320
            :| |....|...||.:|:|.::::|..|.::|:.:|.|. ::||:|:.|:::|.:.:
 Worm   280 VGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLLIMI-------- 335

  Fly   321 QVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPW 366
                                   :.:|||||        |.|:..|
 Worm   336 -----------------------IAITVVVL--------ITELRQW 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	83/371 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	44/210 (21%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	43/197 (22%)
		LGIC_TM	261..>317	CDD:365787	16/55 (29%)
		TM1 helix	261..284	CDD:349850	6/22 (27%)
		TM2 helix	291..315	CDD:349850	7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010