Protein Alignment nAChRalpha6 and lgc-16

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 83/371 - (22%)
• Similarity: 159/371 - (42%)
• Gaps: 90/371 - (24%)

  Fly    30 EKRLLNHLLSTYN-TLERPVAN--ESEPL----------EVKFGLTLQQIIDVDEKNQILTTNAW 81
            ::.|.|.|.:.|: |:....|:  :.|||          .....|...::::|.|..:.::....
 Worm    36 QENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLE 100

  Fly    82 LNLEWNDYNLRWNETEYGGVKDLRITPNKLWKP--------DVLMYNSAD-----EGFDGTYHTN 133
            |...|.|..|.||.:.|..|..:.....|:|.|        :::.:...|     ..|.|..:..
 Worm   101 LVERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQDFRLISIDFTGYLNDY 165

  Fly   134 IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFI 198
            :.|:            ..:.|.:|::.||||.|.|:::|....::..|:. :||....|.|.:.|
 Worm   166 LSVR------------VSANCPMDVSRFPFDSQTCQIRFCLPIFNIRQVK-ILNEIYEGILQEKI 217

  Fly   199 T----NGEWYLLAMPGKKNTIVYACCPEPY--VDI-TFTIQIRRRTLYYFFNLIVPCVLISSMAL 256
            .    |.||.::::..:...:.|   .:.|  :|: .|.|.|||..|||.:.::.|..:|:.:::
 Worm   218 IKTMGNSEWKVVSLTNRVEQLKY---DDDYGNMDLAVFEITIRRNPLYYIYMIVFPSFVINGISI 279

  Fly   257 LG-FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLP 320
            :| |....|...||.:|:|.::::|..|.::|:.:|.|. ::||:|:.|:::|.:.:
 Worm   280 VGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLLIMI-------- 335

  Fly   321 QVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPW 366
                                   :.:|||||        |.|:..|
 Worm   336 -----------------------IAITVVVL--------ITELRQW 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	83/371 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	44/210 (21%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	43/197 (22%)
		Cys-loop	174..188	CDD:349790	7/13 (54%)
		LGIC_TM	261..>317	CDD:476813	16/55 (29%)
		TM1 helix	265..284	CDD:349850	3/18 (17%)
		TM2 helix	291..315	CDD:349850	7/23 (30%)