DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and lgc-15

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_510025.2	Gene:	lgc-15 / 187973	WormBaseID:	WBGene00011356	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	327	Identity:	76/327 - (23%)
Similarity:	142/327 - (43%)	Gaps:	71/327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKRLLNHLLSTYNTLERPVANESEPLE----------------VKFGLTLQQIIDVDEKNQILTT 78
            :..|..:|.|.|:....||..:.:|.:                :.|.|.|.::.:..||..::
Worm    35 QTNLTKNLFSGYDATISPVYTKVDPTQPLGHDPDAPGRWNYTLLLFSLKLVEVTEPQEKVSVV-- 97

  Fly    79 NAWLNLE----WNDYNLRWNETEYGGVKDLRITPNKLWKP----------------DVLMYNSAD 123
                 :|    |.|..|.||:.:|..:..:......:|.|                |..:.....
Worm    98 -----MEVMEYWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVSELVDLRDTDFRLVGITS 157

  Fly   124 EGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNS 188
            .|...|| .:::|..|              |.:|:..||||.|.|:::|....:...::: :.|.
Worm   158 YGMVNTY-VSVLVSAN--------------CPMDVYKFPFDYQTCQIRFCIPVFTSYEVE-IFNE 206

  Fly   189 EDGGDLSD----FITNGEWYLLAMPGKKNTIVYACCPEPYVDI---TFTIQIRRRTLYYFFNLIV 246
            ...|.|:.    .:.|.||.|:.:..:..|:.|   .:.:.::   ||.|:|||..|||.:.:|.
Worm   207 IYAGVLTSNAWKTMGNSEWNLVNLTHRVETLKY---DDGFANLDLGTFEIKIRRNPLYYIYMIIF 268

  Fly   247 PCVLISSMALLG-FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTV 310
            |..:|:.::::| |....|...||.:|:|.::::|..|.::|:.:|.|. .:||:||.|:.:|.:
Worm   269 PSFIINVVSIIGVFLKGADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-TIPLLGVYIITNLVI 332

  Fly   311 FL 312
            .|
Worm   333 ML 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	76/327 (23%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	43/223 (19%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	43/209 (21%)
		LGIC_TM_cation	260..>343	CDD:349853	25/76 (33%)
		TM1 helix	264..285	CDD:349853	5/20 (25%)
		TM2 helix	293..314	CDD:349853	5/20 (25%)
		TM3 helix	324..343	CDD:349853	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010