DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and lgc-13

DIOPT Version :10

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_510023.2 Gene:lgc-13 / 187971 WormBaseID:WBGene00011354 Length:399 Species:Caenorhabditis elegans


Alignment Length:392 Identity:84/392 - (21%)
Similarity:177/392 - (45%) Gaps:64/392 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LFVLLIFLAIIKESCQGPHEKRLL------------NHLLSTYNTLERPVA------NESEPL-- 55
            :|:..|.|.:|..:....::.:|.            |.....:...|:.|:      :.|:||  
 Worm     1 MFLTFILLKLILSTDAFYYDPQLYVPKYRDYLEAQGNLTADLFKNYEKDVSPVYAWFDTSKPLGY 65

  Fly    56 ----EVKFGLTL----QQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLW 112
                ..::..||    .::|.|:|..:.::....|...|.|..|.||.::|..|..:.....|:|
 Worm    66 DPDAPQRYNYTLFLYNLKLIQVNEPEEQVSVVLELMEYWYDPRLSWNASDYKNVTAIFTRQEKIW 130

  Fly   113 KPDVLMY------NSADEGFDGTYHTNIVVKHNGSCLYVPPGI-FKSTCKIDITWFPFDDQHCEM 170
            .|.:..:      :..|:.|      .:|...|...:|....: ..:.|::|:|.||||.|.|::
 Worm   131 SPTLTPFGVNEIIDFRDQDF------RLVCIDNLGMIYDYLSVRVSANCRMDVTKFPFDSQTCQI 189

  Fly   171 KFGSWTYDGNQLDLVLNSE-----DGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDI--- 227
            :|....:  :.|::.:.:|     :...:.:.:.|.||.|:.:..:.:.:.|    ....|:   
 Worm   190 RFSLPIF--SYLEVKIYTELYEGINNYSMFEVMGNSEWELINLTNRVDFLTY----NDRFDVELA 248

  Fly   228 TFTIQIRRRTLYYFFNLIVPCVLISSMALLG-FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMP 291
            .:.|:|.|..||||:.::.|..:|:|::::| |....|...:|.:|:|.::::|..|.::::.:|
 Worm   249 VYEIKIARNPLYYFYMIVFPSFVINSVSIVGVFIKGADKMSRLNVGLTNIMTMTFILGVMSDKIP 313

  Fly   292 TTSDAVPLIGVTILLSLTVFL------NLVAETLPQVSDAIPLLGTYFNC-IMFMVASSVVLTVV 349
            .|.: |||:|:.|:::|.:.|      .::.|....|:..:....:.||. :...:.|.:..|..
 Worm   314 RTGN-VPLLGIYIIVNLLIMLVAIIIVTIITEIRKCVTPKLRKNTSSFNLKLEIFIGSPLEYTCA 377

  Fly   350 VL 351
            |:
 Worm   378 VI 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:455710 84/392 (21%)
LGIC_ECD_nAChR 55..236 CDD:349798 42/205 (20%)
Cys-loop 154..168 CDD:349798 8/13 (62%)
lgc-13NP_510023.2 LGIC_ECD_cation 74..257 CDD:349790 41/194 (21%)
Cys-loop 173..187 CDD:349790 8/13 (62%)
LGIC_TM 259..>335 CDD:476813 24/76 (32%)
TM1 helix 263..284 CDD:349850 5/20 (25%)
TM2 helix 292..313 CDD:349850 4/20 (20%)

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