Protein Alignment nAChRalpha6 and acr-20

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 584
• Identity: 148/584 - (25%)
• Similarity: 260/584 - (44%)
• Gaps: 112/584 - (19%)

  Fly     1 MDSPLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQ 65
            |.|...|::.|...|:.|.:..:      :..:.|.:|..||....|...:..|:||.|.:.|.|
 Worm     1 MSSGRQAAVLLLHSLVLLTVSSD------QYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQ 59

  Fly    66 IIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNS---ADEGFD 127
            ||.|:|..|.|..|||:...|.|..|.|:..::|.|.::.:..:.:|.||..:|||   .|:...
 Worm    60 IISVNEPQQFLMLNAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENR 124

  Fly   128 GTYHTNIVVKHNGSCLYVP---PGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLD-LVLNS 188
            ...|..:.....|:..::.   |.|:|.:|.:::.:||||.|.|.:.|||||:|..::| ...|.
 Worm   125 RLLHAKVTTLGEGNGAFIELLYPTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNE 189

  Fly   189 EDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISS 253
            ......::.|.|..|.:|:....::...|.|||..|..:.|.:.|:|:.|||..|||:|..:|:.
 Worm   190 SQAIGTTNCIENEGWNVLSTSVIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIPTSIITF 254

  Fly   254 MALLGF----TLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNL 314
            ::::||    ::.....||:|||:|.|||:::.:.:|::.||:||..:||||:
 Worm   255 ISIIGFFSTSSINEPREEKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGL------------ 307

  Fly   315 VAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVL--------------NYHHRTADIH---- 361
                             ::..::.:::.|.:.:.||:              |:.:....::
 Worm   308 -----------------FYTSMILLISFSTICSSVVIYVQKQGNLGNPPSKNFMNIARAVNRFIR 355

  Fly   362 -EMPPWIKSVFLQWL-PWILRMGRPGR---------KITRKTILLSNRMKELELKERSSK--SLL 413
             |||..:|..:.|.. ...||..:.||         |:.|:..|    .|:::..:.|||  .:|
 Worm   356 MEMPLIMKQAYAQKAREEKLRRQQMGRKQSLWTRVYKLAREQAL----RKDVQTSQNSSKFNEVL 416

  Fly   414 ANVLDIDD-DFRHTISGSQTAIGSS--ASFGRPTTVEEH------------------------HT 451
            .....||: ..|.||:...|.|..|  .:.|.||...|.                        |.
 Worm   417 TPEKLIDNGGKRCTINKDVTCISDSGIVAMGVPTLASEDDDQDVSLLELETTPTPAMQRPTRLHK 481

  Fly   452 AIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            |..|...| .::.:::: :....|.|.:.||:..||  .|.:::|..||.|....::.::.:.|
 Worm   482 ASTCGSFD-SMMFRQIE-VPVSPRTARNLAEIEYDW--LAALLERIFLITFLFIFVLTSIGINL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	145/574 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	58/187 (31%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	65/213 (31%)
		LGIC_TM_cation	239..>329	CDD:349853	31/118 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910