DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and acr-21

DIOPT Version :9

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_001355512.1 Gene:acr-21 / 185004 WormBaseID:WBGene00000060 Length:635 Species:Caenorhabditis elegans


Alignment Length:626 Identity:195/626 - (31%)
Similarity:289/626 - (46%) Gaps:175/626 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNET 96
            ||...||..||...||..:..||:.|.|..:|.|||||||:|||||||:|:.|.|.||.|.|:..
 Worm    33 RLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIIDVDERNQILTTNSWIRLHWVDYKLVWDPR 97

  Fly    97 EYGGVKDLRITPNKLWKPDVLMYNSADEGF-DGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITW 160
            .|..|..:.|..:|:||||:::||:||..: .....|:::|.:.|:..:....||.|:|.:|:..
 Worm    98 LYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMSTDVIVDYLGNIHWPLSAIFTSSCPLDVKH 162

  Fly   161 FPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYV 225
            :|||.|.|.:|:.||.|||.::||:|.||. |||:::|||.||.|:.:..:||.::|:||||||.
 Worm   163 YPFDRQTCILKYASWAYDGTKIDLLLKSEQ-GDLTNYITNTEWSLIGIRAEKNQVIYSCCPEPYP 226

  Fly   226 DITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESM 290
            .|...:.|.||.::|.||||:||||||.:||:||.:|.|||||:|||:|.|||.||||.:|||.|
 Worm   227 FIDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMPTDSGEKVTLGITSLLSTTVFLMMVAEGM 291

  Fly   291 PTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHH 355
            |.|::|:||||:                             ||...:.:||....:||..:|.||
 Worm   292 PPTAEALPLIGI-----------------------------YFGVTIMLVALGTAMTVFTVNIHH 327

  Fly   356 RTADIHEMPPWIKSVFLQWLPWILRMG-RPGRKI-------------TRKTILLSNRMKELE--- 403
            .....:.:||:::....::|..||.:. .|...|             |..|:..|...|.|.   
 Worm   328 TGVHGYPVPPFLQIFAFRYLSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLHDFD 392

  Fly   404 ------------LKERSSKSLL-ANVLDIDDDFRHTISGSQTA------------IGSSASF--G 441
                        .::.|:.|:: |||....||  ..:.|||::            :.||.|.  |
 Worm   393 ANVAKKEEQYGLQRDMSNLSVISANVHCNPDD--RLLLGSQSSQKNLNKFDSEKNLRSSLSIRSG 455

  Fly   442 RPTTVEEHHTAIG------------CNH------------------------------------- 457
            .||..::.|..:.            .:|                                     
 Worm   456 SPTAKKKGHVRVSNIARSTRIMETDVSHLVSFSSLNSHGTPIDSPIYGRKLGRTQSQTPTSSYRN 520

  Fly   458 ---------------------------------------------KDLHLILKELQFITAR--MR 475
                                                         |:...::..:..|..|  ||
 Worm   521 SNGNGGITSDPLPQQLSNPPKISLTDVDDVFENNENQQPMVDEFEKEFLRVMSMVHGIIERNEMR 585

  Fly   476 KAD-DEAELIG-DWKFAAMVVDRFCLIVFTLFTIIATVTVL 514
            .|: |:.:.|. :|:..|||:|||.|:||.:.|.::|..:|
 Worm   586 VAEKDKRDAIALEWQQVAMVLDRFLLVVFLIGTSMSTFVIL 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 195/626 (31%)
LGIC_ECD_nAChR 55..236 CDD:349798 80/181 (44%)
acr-21NP_001355512.1 LGIC_ECD_nAChR 56..237 CDD:349798 80/181 (44%)
Cys-loop 156..170 CDD:349798 6/13 (46%)
LGIC_TM_cation 239..>327 CDD:349853 50/116 (43%)
TM1 helix 239..263 CDD:349853 15/23 (65%)
TM2 helix 271..292 CDD:349853 14/20 (70%)
TM3 helix 303..325 CDD:349853 6/50 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D363540at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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