Protein Alignment nAChRalpha6 and lgc-6

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_501410.3
• Gene: lgc-6 / 184621
• WormBaseID: WBGene00017544
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 112/492 - (22%)
• Similarity: 206/492 - (41%)
• Gaps: 104/492 - (21%)

  Fly    38 LSTYN--TLERPVANESEPLEVK--FGLTLQQI-------IDVDEKNQILTTNAWLNLEWNDYNL 91
            |.|.|  ||.:.:.|::..:::|  ..||:..|       :.:|:..:.:..:....|.|.|..|
 Worm    14 LETSNTETLLQQLFNQTYDVDMKPSDDLTMVTITPNTFILLSMDQTQETIQYSEEFLLRWYDPIL 78

  Fly    92 RWNETEYGGVKD-LRITPNKLWKPDVLMYNSADEGFDGTYHTNIV---VKHNGSCLYVPPGIFKS 152
            .||::......| ::|:.::.|.|||:..|..|  .|.....::.   :::||......|.:..|
 Worm    79 HWNQSAVSYENDWIKISASRAWIPDVIFTNGID--MDPLLDKDMQMADLRYNGEIRTSRPAVVSS 141

  Fly   153 TCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNS-EDGGDLSDFITNGEWYLLAMPGKKNTIV 216
            .|.::|..||:|.|.|.:..|||.:|...|.:..:: |.......|..|.||.|:::...::...
 Worm   142 PCPLEIDNFPYDVQKCNISMGSWAFDRRFLSVQSSTIEILPQKGRFEGNSEWELISILTVRSDSY 206

  Fly   217 YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLG-FTLPPDSGEKLTLGVTILLSLT 280
            .....|.:.:||:.:.::|:.:||...:..|..::.::.:.| ||  |:|.|...|.     .:.
 Worm   207 DTLLEEWFSEITYVVTLKRKPVYYVLVIQAPTFILCTITIFGLFT--PNSNEDERLS-----KVE 264

  Fly   281 VFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVV 345
            :.||:.|                   ::::.|.||::.:|:.| .:||||.|....:|:|.::.:
 Worm   265 LCLNMFA-------------------AISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFVVTAATI 309

  Fly   346 LTVVVLNYHH--RTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERS 408
            .::::...||  .|:.|                      || |:..|..:|...|.:...:.|.|
 Worm   310 ASIIIQQTHHHVHTSAI----------------------RP-RRWLRCLVLCECRRRRFSISEAS 351

  Fly   409 SKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITAR 473
            :.|    .:|:.:   |.|. |.:.:.||.          |.||:        |:...||    |
 Worm   352 TVS----SVDVPE---HAIQ-SFSILKSSL----------HQTAV--------LVRDTLQ----R 386

  Fly   474 MRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIAT 510
            |....:...|   |.......|..||.:|.:..|:.|
 Worm   387 MSLISENQLL---WLKILDKTDLMCLFLFQVANIVVT 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	112/492 (23%)
		LGIC_ECD_nAChR	55..236	CDD:349798	45/194 (23%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)
lgc-6	NP_501410.3	LIC	1..424	CDD:455710	112/492 (23%)
		LGIC_ECD_cation	42..226	CDD:349790	43/185 (23%)
		Cys-loop	143..157	CDD:349790	6/13 (46%)