DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and lgc-48

DIOPT Version :10

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_506308.3 Gene:lgc-48 / 183638 WormBaseID:WBGene00008223 Length:366 Species:Caenorhabditis elegans


Alignment Length:331 Identity:79/331 - (23%)
Similarity:142/331 - (42%) Gaps:50/331 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 IFLAI-----------IKESCQGPHEKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQII 67
            |||.:           ::..|.  :|.:|:..||  |.|:..:.|..|   .:.|.....:|:|.
 Worm     5 IFLGLLVAVLGEEVHELRSECL--NEAQLMEKLLKGSGYSKHKIPREN---GITVSVEFWIQEIN 64

  Fly    68 DVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVK-DLRI---TPNKLWKPDVLMYNSA-DEGFD 127
            .:.|.........::|..|.|.:||:  ...|..| :|.:   |..|||.|:....||. .|.::
 Worm    65 SISEMTNDFELELFINEMWTDPSLRF--PHLGACKANLTLDQQTLTKLWTPNTCFVNSKFAEIYE 127

  Fly   128 GTYHTNIVVKHNGSCLYVPPGI-FKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDG 191
            .::....:...:...::|...: .|..|.:|:..||.|.|.|.:.:.|:||:..::.|..||:..
 Worm   128 SSFQNVFLTLFDNGTVWVNYRVRVKGACNMDLVDFPMDTQSCRLNYQSFTYNNEEVRLQWNSQRS 192

  Fly   192 G-------DLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVD---ITFTIQIRRRTLYYFFNLIV 246
            .       .::||     |.....|    .::....|....|   :||..:  ||.::||....:
 Worm   193 PVFALQEIRIADF-----WLKDITP----AVIKRDYPAGLWDELVVTFVFE--RRYMWYFLQAYL 246

  Fly   247 PCVLISSMALLGFTLPPDS-GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLT- 309
            |......::.:.|:|.|.: ..:..:||..|||:......:.:::|..| .:..|.|.:|.|:| 
 Worm   247 PTFFSIFISWIAFSLGPQAITPRTMIGVNALLSMIFHFGSIMKNLPRVS-YIKAIDVWMLSSMTF 310

  Fly   310 VFLNLV 315
            |||:|:
 Worm   311 VFLSLI 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:455710 79/331 (24%)
LGIC_ECD_nAChR 55..236 CDD:349798 43/196 (22%)
Cys-loop 154..168 CDD:349798 6/13 (46%)
lgc-48NP_506308.3 LGIC_ECD_GABAAR 52..236 CDD:349791 43/196 (22%)
Cys-loop 155..169 CDD:349791 6/13 (46%)
LGIC_TM_anion 239..358 CDD:349851 22/79 (28%)
TM1 helix 239..262 CDD:349851 4/22 (18%)
TM2 helix 266..290 CDD:349851 5/23 (22%)
TM3 helix 298..324 CDD:349851 9/19 (47%)
TM4 helix 325..358 CDD:349851
Blue background indicates that the domain is not in the aligned region.

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