Protein Alignment nAChRalpha6 and lgc-23

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510016.2
• Gene: lgc-23 / 182622
• WormBaseID: WBGene00007594
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 427
• Identity: 88/427 - (20%)
• Similarity: 158/427 - (37%)
• Gaps: 117/427 - (27%)

  Fly    11 LFVLLIFLAI----------------------IKESCQGPHEKRLLNHLLSTYNTLERPVANESE 53
            |.:|::|..|                      :||...||.:..:.:.|
 Worm     5 LMILVLFNTIPIRVSEADEESERHQAYLDHRKLKEDVLGPLDGSMPSEL---------------- 53

  Fly    54 PLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRIT-----PNKLWK 113
            |:.:...|.|..|..||||...||....:...|:|..|:|:.:.|.|....|:.     ..::||
 Worm    54 PVFIGAQLKLDHISRVDEKTGFLTLALTVKFMWSDERLQWDPSHYSGFTRTRLEFVDFWLYQIWK 118

  Fly   114 PDVLMYNSADEGFDGTYH--TNIVVK---HN-GSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKF 172
            |.:.|.|:.:.....|..  :|.:|:   |: |..:.....:.|:.|.:|...:|.|.|:|...|
 Worm   119 PRIYMTNTYERRQSKTIDLLSNTLVEMDIHSKGFVMTTTKILLKTFCFLDFKGYPHDFQNCSFSF 183

  Fly   173 -----------GS------WTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACC 220
                       ||      :|.|......|:..:| ..::|.:|. :.||.    ....:::...
 Worm   184 IPNMNANDIFLGSSMLKAKFTKDFTDPQQVVRVQD-FQINDVVTE-DLYLF----MNRIVLHDLT 242

  Fly   221 PEP----YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTV 281
            .||    ...::|||.::|:.:|....|..|.:.|.:..::...||  |...|.|.|..|:|..:
 Worm   243 REPRSLVRSFVSFTIVLQRKNVYVHLQLYAPMIFICTCLIISGFLP--SEYALPLLVFNLISEYL 305

  Fly   282 FLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQV--------------------SDAI 326
            :.:.:.:.:||..|..|.|.:....:|       |||:..:                    |...
 Worm   306 YFHNIKDVLPTDFDGTPTIALIATFTL-------AETMSIIGWKMFIITIMTKKQKAYFLNSSKF 363

  Fly   327 PLLGTYFNC------------IMFMVASSVVLTVVVL 351
            ||...:||.            :|:|:.:....::.::
 Worm   364 PLDSGFFNIRVLRRLLTIDKFLMYMLIAQSFGSIFIM 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	88/427 (21%)
		LGIC_ECD_nAChR	55..236	CDD:349798	49/212 (23%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:460752	55/249 (22%)