Protein Alignment nAChRalpha6 and lgc-9

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_500341.1
• Gene: lgc-9 / 182195
• WormBaseID: WBGene00015412
• Length: 464
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 119/524 - (22%)
• Similarity: 207/524 - (39%)
• Gaps: 121/524 - (23%)

  Fly    20 IIKESCQGPHE----KRLLNHLLST----YNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            :::.|..|.:|    |....||:.|    |:...||.|..:.|:.|...:.|..:.:|.|..|:.
 Worm    23 LLQHSQHGHYEDDYIKTEPTHLIETIQRRYDKRVRPFAESNRPVIVHMTIVLGILTEVRENQQVA 87

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEG---FDGTYHTNIVVKH 138
            :.......:|.|..|.||..::.|:..:.:..:.:|.|.:.:|||.|..   .|..|  ::.::|
 Worm    88 SFVISHVQKWRDPKLAWNPADHSGLTQVVMPRSLVWVPKLFIYNSMDTKDMLTDDRY--DVRIQH 150

  Fly   139 NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEW 203
            .|......|....:.|:|:|..||||.|.|.:...|......::|  :|:......|.|..|.||
 Worm   151 TGHVKVNSPQFVSTLCRINIDLFPFDTQFCAIALASPLLSVEEMD--VNATQPPVDSYFSGNAEW 213

  Fly   204 YLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS--- 265
            .::.:..|:...:..  .|...::.:.:.:.||..||...::||..|||::::||...|..:
 Worm   214 QVMNVTVKQMKFMEE--GEYRAEVHYILHLNRRPTYYITVIVVPTFLISALSILGIFSPGSNDGP 276

  Fly   266 -GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLL 329
             .||::||:..||::||.|::||.:||.                              |||||||
 Worm   277 RNEKVSLGLGSLLAMTVLLDIVAGAMPK------------------------------SDAIPLL 311

  Fly   330 GTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPP--WIKSVFLQWLPWILRMGRPGRKITRKT 392
            |.|...::.:.|..|.:::.:|:.........:|||  :.:.:||.    :.|:
 Worm   312 GYYIMLVILLCAIGVAVSMAMLSMSRSCIQTSKMPPPHYYRLLFLN----VCRV----------- 361

  Fly   393 ILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNH 457
                       :|:.|..:.:|                               :.|..|||....
 Worm   362 -----------VKQNSGLNGVA-------------------------------MNEKPTAITPRF 384

  Fly   458 KDLHLILKELQFITARMR---------KADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513
            .||..|..:|..:....|         |.....|:  :|......:|.|.|.:|.:|.::..|..
 Worm   385 PDLIAIYNQLIEVARAQRTYRERIEKQKWQHRVEI--EWNKIFARIDFFFLFLFEMFNVLILVLF 447

  Fly   514 LLSA 517
            |..|
 Worm   448 LRCA 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	118/522 (23%)
		LGIC_ECD_nAChR	55..236	CDD:349798	41/183 (22%)
lgc-9	NP_500341.1	Neur_chan_LBD	42..245	CDD:280998	50/208 (24%)
		Neur_chan_memb	252..>347	CDD:280999	34/124 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010