Protein Alignment nAChRalpha6 and acr-12

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_510262.1
• Gene: acr-12 / 181475
• WormBaseID: WBGene00000051
• Length: 573
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 195/570 - (34%)
• Similarity: 303/570 - (53%)
• Gaps: 99/570 - (17%)

  Fly    12 FVLLIFLAI-------IKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDV 69
            :.|::.:|:       ||.:.: ..|.:|...||..||.:.|||.|.|:.|.|..|.:|.:||||
 Worm    14 WALILLVAVGGTNAFKIKRTAK-DLESQLYEDLLFDYNKVPRPVKNSSDILTVDVGASLIRIIDV 77

  Fly    70 DEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNI 134
            |||||:||||.||.::|||..|.|...:|||:|.|.|..:.:|.||:::||:|....|.|..|:.
 Worm    78 DEKNQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGDPDITILTDA 142

  Fly   135 VVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL---------VLNSED 190
            :|...|:..:.||.|:||.|.||:||||:|.|.||||||:|||.|..:||         .:..:|
 Worm   143 LVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLKQLPQEEVVTITKDD 207

  Fly   191 --------GGDLSDFITNGEWYLLAMPGKKNTIVYA-CC-PEPYVDITFTIQIRRRTLYYFFNLI 245
                    |.|||.|..:.||.||::..::::::|| || ||.|||||:...:||:||::..|||
 Worm   208 NDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEKYVDITYYFGLRRKTLFFTCNLI 272

  Fly   246 VPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTV 310
            :||.|||.:....|.|   |..|:|..::||::||||..::.:.||.||
 Worm   273 LPCFLISILTTFVFYL---SDHKITFSISILVTLTVFFLVLIDLMPPTS---------------- 318

  Fly   311 FLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWL 375
               ||          ||:.|.|....|.:||.|.|::|:.:|:..|:...|:|.|||::|||::|
 Worm   319 ---LV----------IPMFGRYLITTMILVALSTVVSVITVNFRFRSGSAHKMSPWIRAVFLKFL 370

  Fly   376 PWILRMGRPGR-KITRKTILLS--------------------NRMKE-----LELKER-SSKSLL 413
            |.||.|.||.: ::|::..|::                    |:.|.     :.|:.: ||:::|
 Worm   371 PKILLMSRPEKGEVTKQPPLVNAASLVGSNYATAAKAANEYRNKAKGKNNDLMSLRGKPSSQAVL 435

  Fly   414 ANVLDI-----DDDFRHTISGSQTAIGSSASFGRPTTV---EEHHTAIGCNHKDLHLILKELQFI 470
            .|..|:     |....:.:.....|..::|    ||..   .:...:...:......:|.:::||
 Worm   436 NNTFDMRMRNNDSTVENRLKPYLCAQNNNA----PTVAFRKTKRQKSKSVDDVVFMNLLNQVRFI 496

  Fly   471 TARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            ....|..:.|.|:..||.|.|||:||..||:|::.. :.||.::|.:|.:
 Worm   497 AEHFRHNELEGEISDDWTFVAMVLDRLFLIIFSVLN-VGTVFIILESPSL 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	194/565 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	89/199 (45%)
acr-12	NP_510262.1	LIC	14..539	CDD:273305	193/562 (34%)
		Neur_chan_LBD	38..264	CDD:280998	101/225 (45%)
		Neur_chan_memb	271..538	CDD:280999	85/303 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910