Protein Alignment nAChRalpha6 and acr-8

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001361818.1
• Gene: acr-8 / 181246
• WormBaseID: WBGene00000047
• Length: 540
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 173/524 - (33%)
• Similarity: 268/524 - (51%)
• Gaps: 106/524 - (20%)

  Fly    32 RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNET 96
            ::...||..||...||:.|.||.::||||.:|.:||||||.||:||||.||.::|.||.|.|:..
 Worm    27 QMYEDLLYYYNKNVRPIKNASESVKVKFGSSLIRIIDVDEVNQVLTTNLWLEMQWFDYRLMWDPG 91

  Fly    97 EYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWF 161
            .:|.::.|.:..:::|.||:|:||:||.....|..::.:|.:||..::.||.|:||.|.|||.:|
 Worm    92 RWGKIRKLHVPVDQIWIPDILLYNNADGEPHITIMSDAIVYYNGLVVWKPPSIYKSFCSIDIEYF 156

  Fly   162 PFDDQHCEMKFGSWTYDGNQLDL---------VLNSED----------GGDLSDFITNGEWYLLA 207
            |:|.|.|.||||.|||:|..||:         |:|..|          |.|||.:..:.||.|:.
 Worm   157 PYDTQTCWMKFGGWTYNGFLLDVRQLPTTGCEVVNKADDEGEFQFLGRGMDLSGYYPSLEWDLME 221

  Fly   208 MPGKKNTIVYA-CCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLT 270
            :...::..:|| ||.:. |:||||.|:|||:||:|..||::||.:.:.:..:.|.:||.. .|:|
 Worm   222 LNSARHEKIYAGCCGQDFYIDITFKIEIRRKTLFYTINLMIPCTMFAILTSIVFYVPPIE-HKMT 285

  Fly   271 LGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNC 335
            ..::||::||||..::.:.:|.||..:||||..:|.:
 Worm   286 FSISILVTLTVFYLILIDLVPPTSLVIPLIGKYLLFT---------------------------- 322

  Fly   336 IMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMK 400
             ||:|:.|::|:|:.||::.|......||.|:|.||:..||         |.|..||      .:
 Worm   323 -MFLVSISIMLSVISLNFYRRDGSSFPMPHWMKVVFIHTLP---------RYICIKT------AE 371

  Fly   401 ELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPT----TVEEHHTAIGCN----- 456
            |.:..:|.|        .|.|            ||......||:    ||.|..    .|
 Worm   372 EDDGSDRGS--------SISD------------IGPFMDSRRPSPFFITVNERQ----LNGRLSE 412

  Fly   457 ------HKDL-HLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVL 514
                  |.|| ..:::.::||.........|.::..||.:.|.|:||..||:|::..::.|..:|
 Worm   413 LKKKGMHPDLIRNMIQNVEFIAEYFNSLKKEDKVSEDWSYVANVIDRIFLIIFSIMNVVGTWVIL 477

  Fly   515 LSAP 518
            |::|
 Worm   478 LNSP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	172/521 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	84/201 (42%)
acr-8	NP_001361818.1	LGIC_ECD	24..255	CDD:355788	95/227 (42%)
		Neur_chan_memb	260..476	CDD:367256	72/284 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910