Protein Alignment nAChRalpha6 and lgc-11

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_509270.1
• Gene: lgc-11 / 181009
• WormBaseID: WBGene00000061
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 389
• Identity: 100/389 - (25%)
• Similarity: 178/389 - (45%)
• Gaps: 71/389 - (18%)

  Fly     9 LSLFVLLIFLAIIK------ESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQII 67
            ||:.:||.|....|      |.....:|:.|..|||..|....|||.|.|..|.|.....:..::
 Worm     9 LSISILLFFAKCEKVKNKAVEKKDDRNERELAKHLLDDYYQYTRPVRNYSSVLNVTVQPQIYNLV 73

  Fly    68 DVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHT 132
            :|:|:|:.:....|....|.|..|.|:..|:.|::.:.|..:::|.||..::|:.:|       |
 Worm    74 EVNEQNEQIKILLWFPQSWKDDYLTWDPKEWNGIERIIIPKSQIWIPDGYIFNTVEE-------T 131

  Fly   133 NIVVKHNGSCLYVPPG--------IFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSE 189
            ..:..||....|  .|        :...||.:.:..||||.|.|.::||||:|..:.:...:
 Worm   132 EPLENHNARVRY--DGRVEVDFNKLVDLTCPMSVLSFPFDVQLCALQFGSWSYQAHAISFNV--- 191

  Fly   190 DGGDLSDFI----TNGEWYLLAMPGKKNTIVYACCP---EPYVDITFTIQIRRRTLYYFFNLIVP 247
                |..|:    .|.||.:::....|.|..|....   ..|.:|.:.:::||:.|||...:::|
 Worm   192 ----LDTFVPKKSKNSEWDIVSFNATKMTTKYGDTLGGFNVYEEIFYYLELRRKPLYYIVVILLP 252

  Fly   248 CVLISSMALLGFTLP----PDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSL 308
            ..||.:::.:|...|    .|..|.::||:|.:|::.|.|::|...||.:|:.:||:|:.:|:..
 Worm   253 SFLIVTVSNIGLFTPHGVHGDREEHVSLGLTTMLTMAVILDMVTGQMPRSSEGIPLLGMYVLIEF 317

  Fly   309 TVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPP-WIKSVF 371
            .:  :::|                           |:::||::..|.|...:...|| |:..:|
 Worm   318 VI--SVIA---------------------------VLVSVVIIFAHERMLYLDATPPYWVCKLF 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	98/387 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	47/195 (24%)
lgc-11	NP_509270.1	Neur_chan_LBD	36..242	CDD:280998	59/221 (27%)
		Neur_chan_memb	249..>336	CDD:280999	26/115 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010