Protein Alignment nAChRalpha6 and acr-3

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_509129.1
• Gene: acr-3 / 180937
• WormBaseID: WBGene00000043
• Length: 487
• Species: Caenorhabditis elegans
• Alignment Length: 523
• Identity: 175/523 - (33%)
• Similarity: 300/523 - (57%)
• Gaps: 72/523 - (13%)

  Fly    11 LFVLLIFLAIIKESCQGPH--EKRLLNHLLSTYNTLERPVAN-ESEPLEVKFGLTLQQIIDVDEK 72
            ||.::....|.:..|. |:  |:|||:::...||:|.|||.| .|.|:||.|.|....:|:||||
 Worm     6 LFSIITIFLITELQCY-PNSAEERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFVLLINVDEK 69

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            |||:.||.|..::||||.::|:..|:.|:|.:|:.|:|:|.||::::|:||..:..::::|:||:
 Worm    70 NQIMQTNVWPTMKWNDYQMQWDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVSFYSNVVVE 134

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL-VLNSEDGGDLSDFITNG 201
            |.|..|:|||.::||:|.||:.:||||:|.|.:.|||||:..::|.| .|:.:...:|:|::.:|
 Worm   135 HTGDMLWVPPAVYKSSCLIDVEFFPFDEQVCSLTFGSWTFRKDELQLSYLSGKRHVELNDYLPSG 199

  Fly   202 EWYLLAMPGKKNTIVYACCPEPYVD----ITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP 262
            .|.|:..||.            .:|    |::.|:|||:.|:|...||:|.||::.::::.|.||
 Worm   200 VWDLIDAPGL------------LIDERSKISYQIKIRRKALFYTVILIMPTVLMAFLSMMVFYLP 252

  Fly   263 PDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIP 327
            .:|.||:||.::|||:|.|||.:|::.:|.||..:||:...:|  :|..:|::
 Worm   253 AESSEKITLAISILLALVVFLLVVSKILPPTSSTIPLMAKYLL--MTFIMNMI------------ 303

  Fly   328 LLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKT 392
                           :::::|:::|.:.|....|.||.|:|:|||::||.:..|.||  :.|.|.
 Worm   304 ---------------TIMVSVIIINVYFRGPATHIMPNWVKTVFLKFLPVLFVMRRP--ESTEKE 351

  Fly   393 ILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTA--IGSSASFGRPTTVEEHHTAIGC 455
            :.   :||..:.:.||.||.|..... .:|.:.:....||:  .|||:        ||..::
 Worm   352 LA---KMKREKRERRSMKSALKTFFK-RNDAKISEQPKQTSRKDGSSS--------EEKLSS--- 401

  Fly   456 NHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
               |....::.:::||..:...:.......:|||.::|:||..|.:|...|...||.:|||||::
 Worm   402 ---DAKKAIEAIEYITTHLTHDNAFKRQREEWKFVSVVIDRLLLYLFFAVTTGGTVGILLSAPNV 463

  Fly   521 IVQ 523
            ..|
 Worm   464 FEQ 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	171/515 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	72/185 (39%)
acr-3	NP_509129.1	LIC	5..460	CDD:273305	171/515 (33%)
		Neur_chan_LBD	26..226	CDD:280998	85/211 (40%)
		Neur_chan_memb	234..456	CDD:280999	76/270 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910