Protein Alignment nAChRalpha6 and acr-2

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_509128.1
• Gene: acr-2 / 180936
• WormBaseID: WBGene00000042
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 188/604 - (31%)
• Similarity: 300/604 - (49%)
• Gaps: 155/604 - (25%)

  Fly    13 VLLIFLAI-IKESCQGPH-----------------------------------EKRLLNHLLSTY 41
            :|||.:.: :|..|.|.|                                   |.||:..|...|
 Worm     7 ILLILITVFLKVHCNGGHDDEAADFLSHTNIDDPNNSSDPNKNSDQGDTMGEDEDRLVIDLFREY 71

  Fly    42 NTLERPVAN-ESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLR 105
            |.|.|||.| .|.|:.|.||:.:..:|:||||||||.||.||.::|||:.|.||..|||.:.:|.
 Worm    72 NFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLAWNPAEYGNISNLH 136

  Fly   106 ITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEM 170
            :..:::|.||::::|:||..::.::.:|:.|.|:|...:|||.:|||:|:||:.|||||:|.|.:
 Worm   137 VPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRIDVEWFPFDEQCCTL 201

  Fly   171 KFGSWTYDGNQLDL-VLNSEDGGDLSDFITNGEWYLLAMPG--------KKNTIVYACCPEPYVD 226
            .||||||:..::.| ..|:.....|.|:..:|.|.::.:||        |:|.:|
 Worm   202 VFGSWTYNSEEVRLHWYNNIQAVQLHDYSYSGIWDVIDVPGQLVHKPDLKENKMV---------- 256

  Fly   227 ITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMP 291
              |.:.|||:||:|...||:|.||::.::::.|.||.|||||::|.:::||:|.|||.||::.:|
 Worm   257 --FNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLLLALVVFLLLVSKILP 319

  Fly   292 TTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHR 356
            .||: :||:|..:||:..  ||:.|                           ||.|||::|.:.|
 Worm   320 PTSN-IPLMGKYLLLAFV--LNITA---------------------------VVGTVVIVNIYFR 354

  Fly   357 TADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNR--MKELELKERSSKSLL-----A 414
            :|..|:||.|::.|||::||.:|.|.||.|      |.:.|.  ::|....|....||:     |
 Worm   355 SALSHKMPTWVRKVFLEFLPHLLVMKRPER------IPIFNGYFVEEYCASEIFDASLVMPSMTA 413

  Fly   415 NVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGC------------------------ 455
            .:|.......:..:.|.|:.|.|:         |||.  .|
 Worm   414 TMLPFLQVTTNLKAASSTSSGQSS---------EHHE--NCSKWKKRLSIRMSKRRAPRARLDDD 467

  Fly   456 ----------NH---------KDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIV 501
                      ||         |::...::.:.:|...|::.....::..|||:.|||:||..|::
 Worm   468 SEDIIDDTNGNHVDSLQEKISKEMKTTVEAIAYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLI 532

  Fly   502 FTLFTIIATVTVLLSAPHI 520
            |...|:..|:.::.||||:
 Worm   533 FFGVTLGGTLGIICSAPHV 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	184/599 (31%)
		LGIC_ECD_nAChR	55..236	CDD:349798	72/189 (38%)
acr-2	NP_509128.1	LIC	54..544	CDD:273305	177/548 (32%)
		Neur_chan_LBD	60..265	CDD:280998	86/216 (40%)
		Neur_chan_memb	272..544	CDD:280999	88/318 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910