Protein Alignment nAChRalpha6 and acr-16

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_505207.1
• Gene: acr-16 / 179235
• WormBaseID: WBGene00000055
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 248/539 - (46%)
• Similarity: 330/539 - (61%)
• Gaps: 68/539 - (12%)

  Fly     9 LSLFVLLIFLAIIKESCQGP-HEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            :|:..|||..||:.....|. .|:||...|:..||.|||||||.|||:.|...:.||||||||||
 Worm     1 MSVCTLLISCAILAAPTLGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEK 65

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            ||::..||||:..||||||.|::.|||.:.|:|....|:||||||:|||.|..||.||.||::|.
 Worm    66 NQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVY 130

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG-DLSDFITNG 201
            ..|...:|||||||.:|||||.|||||:|.|..|||||||||.:||  |....|| |:|::|:||
 Worm   131 STGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLD--LQPATGGFDISEYISNG 193

  Fly   202 EWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSG 266
            ||.|.....::|...|.||||||.|:.|.:.:|||||||.||||:||:|.:.|.|||||||||:|
 Worm   194 EWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAG 258

  Fly   267 EKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGT 331
            ||:||.:|:|||:..||::|:|..|.||:||||:|:
 Worm   259 EKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGI----------------------------- 294

  Fly   332 YFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTI--L 394
            :|.|.|.:|.:|.|.||.|||.|:||.:.|:|.||.:::.|.|:||||||.|||..:|..::  |
 Worm   295 FFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIPWILRMKRPGHNLTYASLPSL 359

  Fly   395 LSNRMKELELKERSSKSLLANVLD----------IDDDFR-------HTISGSQTAIGS-----S 437
            .|.:      ..|.|:||:.|:.|          .|.|.|       .::|...|::||     .
 Worm   360 FSTK------PNRHSESLIRNIKDNEHSLSRANSFDADCRLNQYIMTQSVSNGLTSLGSIPSTMI 418

  Fly   438 ASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVF 502
            :|.|..|.|.:..|.:     .||.|..||:.:|.||.:.|.|.:...:||||||||||.||.||
 Worm   419 SSNGTTTDVSQQATLL-----ILHRIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVF 478

  Fly   503 TLFTIIATVTVLLSAPHII 521
            |:|.|::|:.:..|||:::
 Worm   479 TIFIIVSTIGIFWSAPYLV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	244/531 (46%)
		LGIC_ECD_nAChR	55..236	CDD:349798	100/181 (55%)
acr-16	NP_505207.1	LIC	6..493	CDD:273305	244/528 (46%)
		Neur_chan_LBD	23..229	CDD:280998	117/207 (57%)
		Neur_chan_memb	236..490	CDD:280999	114/293 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I838
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm4815
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.960