Protein Alignment nAChRalpha6 and lgc-10

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001293778.1
• Gene: lgc-10 / 177409
• WormBaseID: WBGene00022247
• Length: 450
• Species: Caenorhabditis elegans
• Alignment Length: 366
• Identity: 91/366 - (24%)
• Similarity: 161/366 - (43%)
• Gaps: 42/366 - (11%)

  Fly     5 LPASLSLFVLLIFLAIIKES-CQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIID 68
            :|..:..|..|..|.::.|: |.......:||.:...|:....|..  ..|:.|...:.|..:|:
 Worm     1 MPKMIQRFFSLFSLLLVNETMCVHNETSAILNDIFVGYDRRVLPFV--QGPVLVNMTIVLGILIE 63

  Fly    69 VDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYH-T 132
            :.|..|:..........|.|..|.|:.::|.|.:::.:....:|.|.:.:|||.:.....|.: .
 Worm    64 LKENQQLAAYVISHTQRWYDGRLSWDPSKYRGQREVIVPQTMVWIPKLFVYNSLESKDMLTENRA 128

  Fly   133 NIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDF 197
            ::.:.|||......|...::.|:|....||||.|.|.:...|...:.|  ::|:|:......|.|
 Worm   129 DVRLYHNGRIKINIPQYVQAICRIQTESFPFDCQFCAVALASPLLNVN--EMVVNATQPPRDSYF 191

  Fly   198 ITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP 262
            ..|.||||..:..:..|....  .|..|:|.:...::||.:||...::.|..|||::::||...|
 Worm   192 SGNAEWYLFNVTVRHMTFEEE--GESRVEIHYVFHLQRRPIYYITVIVAPTFLISALSILGIFSP 254

  Fly   263 PDS----GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVS 323
            ..:    .||::||:..||::||.|.:||.:||.::|
 Worm   255 GSNDGPRNEKVSLGLGSLLAMTVLLGIVAGAMPKSND---------------------------- 291

  Fly   324 DAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMP 364
              |||||.|...::.:.|.:|.::::.|..........:||
 Worm   292 --IPLLGYYILAVIVLCAVAVAISMMFLAVTRHYIQKEQMP 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	90/360 (25%)
		LGIC_ECD_nAChR	55..236	CDD:349798	44/181 (24%)
lgc-10	NP_001293778.1	Neur_chan_LBD	28..229	CDD:280998	50/206 (24%)
		Neur_chan_memb	236..>342	CDD:280999	32/125 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010