Protein Alignment nAChRalpha6 and cup-4

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 489
• Identity: 93/489 - (19%)
• Similarity: 172/489 - (35%)
• Gaps: 183/489 - (37%)

  Fly    12 FVLLIFLAIIKESC----QG-----------------PHEKRLLNHLLSTYNTLERPVANESEPL 55
            |:|:.:|.|.|:..    ||                 .|:..|...:...||...||:.|.|.|
 Worm     9 FILIFYLPIQKKHVNSQQQGIDSDDGDAESFFNKSYSEHQSALEQKIFRGYNPKNRPMKNASFP- 72

  Fly    56 EVKFGLTLQQI------IDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKP 114
                  |:..:      :.::::.|.:|.:..:.:.|.|..|.|:..::..::..|:...::|:|
 Worm    73 ------TIVDVHWHIIHVSINQREQTMTVHGHIYMRWFDEFLVWDPKDFNNIQYARVKKWQVWQP 131

  Fly   115 DVLMYNSAD---EGFDGTYHTNIVVKHNGSC-----LYVPPGIFKSTCKIDITWFPFDDQHCEMK 171
            .:.:.|||.   ..||.:...:::::..|..     :| |....|..|..|.|.:|:|...|.:.
 Worm   132 KIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMY-PTFSIKVGCAFDFTDYPYDLNKCAIN 195

  Fly   172 -FGSWTYDGNQL------------------------DLVLNSEDGGDLSDFITNGE--------- 202
             |.:.|....||                        |..:.:.....|  :.|||.
 Worm   196 LFSTSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSSSAL--YYTNGNITSSAPITG 258

  Fly   203 ------WYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTL 261
                  |.:||:                     |:...|.:..:...::.||::::|:..:.|.:
 Worm   259 FDLGSTWSMLAV---------------------TVSFVRHSPLFEAAVVTPCIVVASLISMTFFI 302

  Fly   262 PPDSGEKLTLGVTILLSL------TVFLNLVAESMPTTSDAVP----LIGVTILLSLTVFLNLVA 316
              ||     |..|.||.:      .:||:.:.|.:|.:...:|    |||:   |..|..|.||.
 Worm   303 --DS-----LSSTFLLMMLHFYVQLIFLHDLVEKLPLSVSEIPFCIKLIGI---LMYTNGLTLVL 357

  Fly   317 ETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFL--QWLPWIL 379
            .       :..|.|:|:.|                          .:|..:..:|:  :::|
 Worm   358 H-------SSLLCGSYYKC--------------------------PVPQQLNKIFVIEEYIP--- 386

  Fly   380 RMGRPGRKITRKTILLSNRMKE-LEL-KERSSKS 411
                             |..|| ::: ||.|:||
 Worm   387 -----------------NTFKEKVQIKKEESNKS 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	93/489 (19%)
		LGIC_ECD_nAChR	55..236	CDD:349798	38/234 (16%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)
cup-4	NP_498710.2	LGIC_ECD_cation	73..246	CDD:349790	31/175 (18%)
		Cys-loop	178..192	CDD:349790	5/13 (38%)