DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and eat-2

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_496959.1	Gene:	eat-2 / 175072	WormBaseID:	WBGene00001133	Length:	474	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	187/529 - (35%)
Similarity:	272/529 - (51%)	Gaps:	91/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQIL 76
            |..||.|..|:.......|.|||..|...|:.:|||||:..:|:.||..|.|||::||||:||::
Worm     7 FFTLILLVSIERVYSSDEEYRLLKDLREGYDPVERPVADHRKPVNVKLRLILQQLVDVDERNQVI 71

  Fly    77 TTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGS 141
            |...|....||||.|||:..|||.:..|:|....|||||:|::|||:|.||.::..::||..||.
Worm    72 TLVVWNQYTWNDYKLRWSPEEYGNITTLQIPHGTLWKPDILLFNSANEHFDASFPVHMVVSSNGD 136

  Fly   142 CLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSED--GG---DLSDFITNG 201
            .|:.||||...:|.:.:||||:|.|.|.:||||||| |.:|||.::..|  .|   ||..:|.||
Worm   137 VLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTY-GKKLDLQIDDSDLPDGHKMDLQYYIPNG 200

  Fly   202 EWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSG 266
            |:.|||.|..:.:..:  ..|.||::.|.:.::|||:||..|.|||.:|||...:||||:||:.|
Worm   201 EFDLLATPAFRKSTTF--LDETYVELYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPPECG 263

  Fly   267 EKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGT 331
            ||:||.:|..||:.|||.:|:|..|.||:::|:|.....||:.:                  ||.
Worm   264 EKITLQITNFLSVMVFLAMVSEVAPPTSESIPIIAAFFSLSIVI------------------LGL 310

  Fly   332 YFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRK----- 391
                       |:..:::::|...|....|.|..|.:.|||:||||.|.|.||.....|.
Worm   311 -----------SICASLIIVNIFFRHPKTHRMGDWTRYVFLEWLPWFLLMSRPEHTFCRPRREEE 364

  Fly   392 ----------TILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTV 446
                      |.||.|:      :.:....||.|              ||..:.|:..:     :
Worm   365 KNDEEAGGDGTKLLENQ------QHQPRPRLLVN--------------SQLVMDSTVPY-----L 404

  Fly   447 EEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATV 511
            ||              |:..|:...|::...::|.|.|.:|:|.|||:||..|.:||......|.
Worm   405 EE--------------IIGYLKVFKAKLDDDEEEEEEILNWRFMAMVIDRLSLFLFTGLIFGTTA 455

  Fly   512 TVLLSAPHI 520
            .:....|::
Worm   456 LIFAFCPNL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	186/524 (35%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	82/185 (44%)
eat-2	NP_496959.1	LIC	3..459	CDD:273305	186/522 (36%)
		Neur_chan_LBD	25..234	CDD:280998	95/211 (45%)
		Neur_chan_memb	242..456	CDD:280999	81/281 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.890