Protein Alignment nAChRalpha6 and acr-7

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_495647.1
• Gene: acr-7 / 174262
• WormBaseID: WBGene00000046
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 201/563 - (35%)
• Similarity: 294/563 - (52%)
• Gaps: 85/563 - (15%)

  Fly     5 LPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDV 69
            ||  ::||.|::|.....|..:  .|.:|...||:.|:.|.|||.|..:.|.|...:.:||::.|
 Worm    10 LP--VALFFLIVFNGFTVEGSK--KEAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLV 70

  Fly    70 DEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRIT-PNKLWKPDVLMYN----SADEGFDGT 129
            |.|:|::..||||...|.|:.||||..:|..:..:|.. .:::|:||:|:||    ...|.||.|
 Worm    71 DAKHQMIEVNAWLKYIWTDFRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDIT 135

  Fly   130 YHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL----VLNSED 190
            |.||.|...:|...::||||||.:||:|||.||||:|.|.||||||||.|..|||    |...|.
 Worm   136 YKTNAVAYSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLRLDVVKGQEP 200

  Fly   191 GGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMA 255
            ..|||.:||||||:||:.|.::....|.||.|||..:.|.:.:||||.||.||:::|.:|:|.|:
 Worm   201 SADLSTYITNGEWHLLSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTLLVSFMS 265

  Fly   256 LLGFTLP-PDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETL 319
            ||.|.|| .|..||:.|..|||||:..||.:::|..||||:||||:||
 Worm   266 LLAFCLPATDLSEKIGLQTTILLSVCFFLTILSEMTPTTSEAVPLLGV----------------- 313

  Fly   320 PQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP 384
                        :|:.:.|:||.|...|::|||..:|....|.:.|..:|:||:.|||::.|.||
 Worm   314 ------------FFSALTFIVAMSTTFTILVLNIRYRQITNHYLSPMFRSIFLECLPWLMMMKRP 366

  Fly   385 GRKITRKTILLSNRMKELE-----LKERSSKSLLA---NVLDIDDDF-----RHTISGSQTAIGS 436
            ..|..|.:   |.|....:     .|....||:|.   |...|:.:.     ..|:|.:: .:|.
 Worm   367 DHKFRRGS---SYRDSSADQCVQCAKNAELKSILRGTDNQQQIETNTFYPFPTETLSLNR-KVGD 427

  Fly   437 SASFGRPTTVEEH-------HTAIGC------NHKDL-----------HLILKELQFITARMRKA 477
            .....|...:.|.       |..:.|      |..:|           .:::.:::.|..|:...
 Worm   428 GLFIQRRCQIHEEARSEKFTHGMLACEKSLRENGSELANILVTILKMYEVMVSQVERIRKRIALK 492

  Fly   478 DDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            ....::..:|||||..|||||||:||:..||... :.::.|.|
 Worm   493 RKRKDIQDEWKFAAQAVDRFCLIIFTIVFIICCF-IFVAIPPI 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	197/552 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	86/189 (46%)
		Cys-loop	154..168	CDD:349798	10/13 (77%)
acr-7	NP_495647.1	LIC	28..524	CDD:455710	191/530 (36%)
		LGIC_ECD_nAChR	56..246	CDD:349798	86/189 (46%)
		Cys-loop	160..174	CDD:349798	10/13 (77%)