Protein Alignment nAChRalpha6 and unc-29

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_492399.1
• Gene: unc-29 / 172703
• WormBaseID: WBGene00006765
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 516
• Identity: 171/516 - (33%)
• Similarity: 283/516 - (54%)
• Gaps: 69/516 - (13%)

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESE-PLEVKFGLTLQQIIDVDEKNQILT 77
            ::|||.||........|:||:..:...||:|.:||.|.|| ||.||..|.|..:|:||||:|::.
 Worm    14 VVIFLVIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLLINVDEKDQVMH 78

  Fly    78 TNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSC 142
            ||.||.|:|:|:.::||...||.:|.:|::|:|:|.||::::|:||..::.::..|:|:.|.|..
 Worm    79 TNVWLTLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVINHKGDM 143

  Fly   143 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLA 207
            |:|||.|:||:|.||:.:||||:|.|.:.||||||:.|::.|.....:..|:|::..:..|.::.
 Worm   144 LWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEFVQAELVDVSEYSASSIWDVID 208

  Fly   208 MP----GKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEK 268
            :|    .|::.            |.|.::|||:||:|...||:|.||::.:::..|.||.|||||
 Worm   209 VPASLVNKRSR------------IEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPTDSGEK 261

  Fly   269 LTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYF 333
            :||.:::|||:.|||.||::.:|.||..:||:...:|  ||..||::
 Worm   262 ITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLL--LTFVLNVI------------------ 306

  Fly   334 NCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP----GRKITRKTIL 394
                     ::::||:::|.:.|....|.||.|::.||||:||.::.|.||    .|...|..:.
 Worm   307 ---------TILVTVIIINVYFRGPRTHRMPQWVRVVFLQFLPKLVCMKRPKSASERSAVRSGMA 362

  Fly   395 LSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKD 459
            ....:.:..|...:...|..:..|.....|:|.|..     :||.:...|              |
 Worm   363 QLPGVGQFTLSPSAHHPLCPSADDRTTTIRNTASNE-----TSAYYPLST--------------D 408

  Fly   460 LHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            ....:..:::||..:::.:.......|||:.||::||..|.||...|:..|..:|.||||:
 Worm   409 ALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFGITVGGTCGILFSAPHV 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	167/511 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	69/184 (38%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
unc-29	NP_492399.1	LIC	6..466	CDD:455710	167/511 (33%)
		LGIC_ECD_nAChR_proto_beta-like	29..230	CDD:349833	82/212 (39%)
		Cys-loop	155..169	CDD:349833	8/13 (62%)