Protein Alignment nAChRalpha6 and unc-63

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_491533.2
• Gene: unc-63 / 172150
• WormBaseID: WBGene00006797
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 541
• Identity: 191/541 - (35%)
• Similarity: 280/541 - (51%)
• Gaps: 91/541 - (16%)

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            :||||.:...:.......||...|::.||.|.|||:...|.|.|.|.|.|.|::||.|||||:||
 Worm    11 ILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLDVHEKNQIMTT 75

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            |.||...|.||.|||:..|||||:.|.:..:.:|.|||::||:||..:..|..|...:.:||:..
 Worm    76 NVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTKAKLTYNGTVE 140

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL------------------------ 184
            :.||.|:||.|:||:.:||||.|.||||||||||.|.::||
 Worm   141 WAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEEDVEGVDGPTKE 205

  Fly   185 -VLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPC 248
             |...:.|.||||:..:.||.:|.:|||:::..|.||..|::|||:.|.:||:||:|..|||.|.
 Worm   206 IVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLIFPS 270

  Fly   249 VLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLN 313
            |.||.:..|.|.||.|.|||::|.::||:|||||..|:.|.:|:||..:||||..:|.:
 Worm   271 VGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFT------ 329

  Fly   314 LVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWI 378
                                   |.:|..|||:|||.||.|:|:...|.||.|:|.:|:.:||..
 Worm   330 -----------------------MVLVTLSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKY 371

  Fly   379 LRMGR---------PGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAI 434
            |.|.|         |.||...:.               |:.|:..|         |.:..:...:
 Worm   372 LLMTRPQPPGHHSKPNRKFDSRA---------------STFSIGVN---------HVLGQNSELL 412

  Fly   435 GSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCL 499
            ....:..|    ||....:..::..:...::.:.:|...::..:|:.::|.|||:.::|:||..|
 Worm   413 SPGLNSNR----EESSFTLPRDNSPVRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFL 473

  Fly   500 IVFTLFTIIATVTVLLSAPHI 520
            |.||......||.::..||.|
 Worm   474 ITFTFACAFGTVVIIARAPSI 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	188/536 (35%)
		LGIC_ECD_nAChR	55..236	CDD:349798	89/205 (43%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
unc-63	NP_491533.2	LIC	6..487	CDD:455710	188/532 (35%)
		LGIC_ECD_nAChR_proto_alpha-like	26..261	CDD:349832	101/234 (43%)
		Cys-loop	151..165	CDD:349832	8/13 (62%)