Protein Alignment nAChRalpha6 and unc-38

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_491472.1
• Gene: unc-38 / 172105
• WormBaseID: WBGene00006774
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 186/540 - (34%)
• Similarity: 283/540 - (52%)
• Gaps: 89/540 - (16%)

  Fly     9 LSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKN 73
            |.|.:||..::.||.:......|||.:.|:..||...||..:.::||.:|..|.|.|||||.|.:
 Worm     6 LFLLLLLFCISFIKLTEGNEDAKRLYDDLMVNYNRHRRPSTSPNKPLTIKLKLRLSQIIDVHEID 70

  Fly    74 QILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKH 138
            ||:|.:.||...|.|..|.|:...||||..|.:....:|.||:::||:||..::.|..|...:.:
 Worm    71 QIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYNITISTKATLHY 135

  Fly   139 NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN---------------- 187
            .|...:.||.||||.|:||:.|||||:|.|.:||||||:..|.|.:.||
 Worm   136 TGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLRYEEEIDEKGII 200

  Fly   188 -----SEDGGDLSDFITNGEWYLLAMPGKKNTIVY-ACCPE-PYVDITFTIQIRRRTLYYFFNLI 245
                 :|||.||||:..:.||.:::...|:....| :|||: .|:|:|:.:|:||:.|:|..||:
 Worm   201 DNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKNYPSCCPQSAYIDVTYYLQLRRKPLFYTVNLV 265

  Fly   246 VPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTV 310
            .|||.||.:.:|.|.||.|||||:||.::||::||:|..|:.|.:|.||..:||||..:|.:
 Worm   266 FPCVGISFLTILVFYLPSDSGEKVTLCISILVALTIFFLLLTEIIPATSITLPLIGKYLLFT--- 327

  Fly   311 FLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWL 375
                                      |.||..|||:||:.||.|.||...|.||.|:|.|||:||
 Worm   328 --------------------------MVMVTLSVVVTVISLNLHFRTPTTHLMPNWVKKVFLKWL 366

  Fly   376 PWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLA------NVLDIDDDFRH-TISGSQTA 433
            |.:|.|.||          :.:..::.:.|::.....:|      .|.::.::.|: ||..:
 Worm   367 PKLLFMRRP----------IDDYEEKFDDKKKPKDGKIALSVHAHRVSNVGNNIRNATIDDT--- 418

  Fly   434 IGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC 498
              ....:..|..|:               ..:.:.||...::|.|.:.::..|||:.|||:||..
 Worm   419 --IQKMYYSPPVVK---------------AFENICFIAELLKKKDRDDKIDEDWKYVAMVLDRLF 466

  Fly   499 LIVFTLFTIIATVTVLLSAP 518
            |::|::...:.||.:||.||
 Worm   467 LLIFSIACFVGTVIILLRAP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	183/535 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	79/203 (39%)
unc-38	NP_491472.1	Neur_chan_LBD	27..257	CDD:280998	89/229 (39%)
		LIC	29..483	CDD:273305	175/512 (34%)
		Neur_chan_memb	264..481	CDD:280999	84/275 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910