Protein Alignment nAChRalpha6 and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_061506567.1
• Gene: nAChRbeta2 / 1272992
• VectorBaseID: AGAMI1_002531
• Length: 530
• Species: Anopheles gambiae
• Alignment Length: 540
• Identity: 198/540 - (36%)
• Similarity: 297/540 - (55%)
• Gaps: 82/540 - (15%)

  Fly     9 LSLFVLLIFLAIIKESCQ--------GPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQ 65
            |:..|:|:.| :...|.|        .|..|||.:.|||.||.|.|||.|.:|.|.|..||.|.|
Mosquito    12 LNAKVILLCL-VASSSAQASVAHIEANPDAKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 75

  Fly    66 IIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTY 130
            :|:|..:||::|||.|:..:|.||.|||:..|||||:.|.:...::|.||:::||:.|..::.|.
Mosquito    76 LIEVSLRNQVMTTNLWVKQKWFDYKLRWDPEEYGGVEMLYVPSEQIWLPDIVLYNNWDGNYEVTL 140

  Fly   131 HTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQ-----LDLVLNS-- 188
            .|...:|:.|...:.||.|:||:|::::.:||:|:|.|.||||||||:|.|     ||.:..|
Mosquito   141 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQTCLMKFGSWTYNGAQVELRHLDQIPGSNL 205

  Fly   189 -EDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLIS 252
             :.|.|||:|..:.||.:|.:|..:|...|.|||||:.||||.:.:||:||:|..|||:|||.|:
Mosquito   206 VQIGIDLSEFYLSVEWDILEVPASRNEEYYPCCPEPFSDITFKLTMRRKTLFYTVNLIIPCVGIT 270

  Fly   253 SMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAE 317
            .:.:|.|.||.|||||:||.::||:|||||..|:||.:|.||.||||:|..:|.:
Mosquito   271 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFT---------- 325

  Fly   318 TLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMG 382
                               |.:|:.||..||.|||..:|:...|:|.|:::.:||:.:|.||.|.
Mosquito   326 -------------------MILVSLSVWTTVCVLNVWYRSTSTHKMSPFVRRLFLEIMPKILMMR 371

  Fly   383 R------------PGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIG 435
            |            |....|          .|:|:          :|.|...:|:.. ..|...||
Mosquito   372 RAKYTLPDYDDSTPSNGYT----------NEIEM----------SVSDFPGEFKEG-GDSFDNIG 415

  Fly   436 SSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLI 500
            .:.|.|   :||..:........::...::.::||...::.||.:.|::.||||.:||:|||.|.
Mosquito   416 VNLSHG---SVEAENVIPKQLSPEVLSAIQAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLW 477

  Fly   501 VFTLFTIIATVTVLLSAPHI 520
            |||:..|..|..::..:|.:
Mosquito   478 VFTISCIFGTFGIIFQSPSL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	196/533 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	81/188 (43%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)
nAChRbeta2	XP_061506567.1	None