Protein Alignment nAChRalpha6 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_309158.3
• Gene: nAChRbeta1 / 1270461
• VectorBaseID: AGAMI1_011382
• Length: 519
• Species: Anopheles gambiae
• Alignment Length: 563
• Identity: 205/563 - (36%)
• Similarity: 305/563 - (54%)
• Gaps: 110/563 - (19%)

  Fly     6 PASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |:.|.|.|||.....:........|:||:..|...||.|.|||.|.::.::|:|||...|:|:|:
Mosquito     3 PSVLILSVLLALQQYLGMGSCSEDEERLVRDLFRGYNKLIRPVQNMTQKVDVRFGLAFVQLINVN 67

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |||||:.:|.||.|.|:||.|:|:|.:|||:..||:.|:|:||||::::|:||..::..|.:|::
Mosquito    68 EKNQIMKSNVWLRLVWSDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVL 132

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL-NSEDGGDLSDFIT 199
            :..||..|:|||.|::|:|.||:|:||||.|.|.|||||||::|:|:.|.| |:::..||||:..
Mosquito   133 IYPNGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWK 197

  Fly   200 NGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD 264
            :|.|.::.:|...|  ||...|.. .||||.|.|||:||:|..|||:|.||||.:.:|.|.||.:
Mosquito   198 SGTWDIIEVPAYLN--VYEGNPTE-TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 259

  Fly   265 SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLL 329
            :|||:|||::|||||.|||.||::.:|.||..:|||...:|  .|..:|.|
Mosquito   260 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLL--FTFIMNTV-------------- 308

  Fly   330 GTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTIL 394
                         |:::||:::|::.|....|.||.||:||||.:||.:|.|.||     |||
Mosquito   309 -------------SILVTVIIINWNFRGPRTHRMPMWIRSVFLHYLPAMLLMKRP-----RKT-- 353

  Fly   395 LSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNH-- 457
               |::  .:.|....|:...        .||          ..|:|.|..:.:|.:|:|...
Mosquito   354 ---RLR--WMMEMPGMSVPPQ--------PHT----------HPSYGSPAEIPKHISALGAKQSK 395

  Fly   458 ------KDLH-------------------------------LIL--------KELQFITARMRKA 477
                  .|||                               ::|        :.::||...:|..
Mosquito   396 MEVMELSDLHHPNCKMNRKLNSGDLGIGADSCRRESESSDSILLSPEASKATEAVEFIAEHLRNE 460

  Fly   478 DDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHI 520
            |...:...|||:.|||:||..|.:|.:.|...||.:|:.||||
Mosquito   461 DLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHI 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	199/553 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	86/181 (48%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
nAChRbeta1	XP_309158.3	LIC	6..498	CDD:455710	199/553 (36%)
		LGIC_ECD_nAChR_proto_beta-like	26..232	CDD:349833	98/208 (47%)
		Cys-loop	151..165	CDD:349833	9/13 (69%)